PMID: 3764341Aug 1, 1986Paper

Effect of splenectomy on circulating haematopoietic progenitors in myelofibrosis

Scandinavian Journal of Haematology
S PartanenP Pantzar

Abstract

The effect of splenectomy on peripheral blood CFU-GM and BFU-E numbers was studied in a patient with myelofibrosis. The numbers of CFU-GM and BFU-E were twice as high in the splenic venous blood as in the peripheral blood. The number of CFU-GM in peripheral blood decreased to 20% and that of BFU-E to 7% of the presplenectomy level at 1 wk after the operation. The progenitor numbers recovered to reach the presplenectomy level within 4-6 w after splenectomy. This effect of splenectomy was different from that seen in 3 patients with Hodgkin's disease, in whom increased numbers of progenitors were observed after a small initial notch.

References

Sep 1, 1979·British Journal of Haematology·H P KoefflerD W Golde
Oct 1, 1978·Scandinavian Journal of Haematology·J M GoldmanK H Th'ng
Nov 1, 1980·Proceedings of the Society for Experimental Biology and Medicine·J J KirshnerS A Landaw
Oct 1, 1982·Scandinavian Journal of Haematology·S PartanenP Vuopio

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Citations

Nov 8, 2001·Leukemia & Lymphoma·R A Mesa, A Tefferi

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