Effect of splenectomy on slowing human immunodeficiency virus disease progression

Archives of Surgery
C M TsoukasP Gold

Abstract

Lymphoreticular tissue is the most important site for human immunodeficiency virus (HIV) replication in HIV-infected individuals. To compare the long-term effect of splenectomy on survival and time to development of acquired immunodeficiency syndrome in subjects who had undergone splenectomy with subjects who had not undergone splenectomy. A cohort study with a follow-up of up to 13.4 years. Subjects were recruited from a hospital outpatient clinic population and a multicenter study of patients with hemophilia. Forty-five HIV-infected individuals were observed prospectively for up to 13.4 years (17 had undergone splenectomy and 28 had not undergone splenectomy). Five subjects underwent splenectomy before acquiring HIV infection and 12 underwent splenectomy during the asymptomatic phase of HIV infection. The group who did not undergo splenectomy consisted of HIV-infected individuals who were asymptomatic at study enrollment. A Cox proportional hazards model was used to test the effects of splenectomy on survival and time to development of acquired immunodeficiency syndrome when adjusting for potential confounders (age, initial CD4+ cell count, and treatment with antiretroviral drugs). Splenectomy was treated as a time-dependent ...Continue Reading

Citations

Feb 12, 2002·Journal of Virology·Stefan MüllerChristoph Mueller
Aug 17, 2011·Journal of Medical Case Reports·Adriana ToroIsidoro Di Carlo
Aug 21, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J M Kilby
Nov 25, 2003·Hematology·Paul A VolberdingAlexandra M Levine
Mar 3, 2020·Parasite Immunology·Alischa HenningAndrew Lambert Leisewitz

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