PMID: 29928Oct 1, 1978Paper

Effect of splenectomy on the expression of regulatory T cell activity

The Journal of Immunology : Official Journal of the American Association of Immunologists
D F AmsbaughP J Baker

Abstract

The effect of adult splenectomy on the expression of suppressor and amplifier T cell activity was examined with respect to the serum antibody response to Type III pneumococcal polysaccharide (SSS-III) by using a sensitive radioimmunoassay. Suppressor T cell activity, as measured by the degree of low-dose paralysis induced, was not impaired in the least by splenectomy; however, amplifier T cell activity was almost completely eliminated within 7 days after splenectomy. These findings indicate that suppressor T cell activity is not confined solely to the spleen, the major site of antibody synthesis after immunization with SSS-III, and that the spleen may be an important site for the generation and/or maintenance of amplifier T cell activity.

Related Concepts

Antibodies, Bacterial
Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine)
Dose-Response Relationship, Immunologic
Hemolytic Plaque Technique
Mice, Inbred BALB C
Polysaccharides, Bacterial
Splenectomy
Streptococcus pneumoniae
T-Lymphocyte

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