Effect of SR-microCT radiation on the mechanical integrity of trabecular bone using in situ mechanical testing and digital volume correlation

Journal of the Mechanical Behavior of Biomedical Materials
M Peña FernándezGianluca Tozzi

Abstract

The use of synchrotron radiation micro-computed tomography (SR-microCT) is becoming increasingly popular for studying the relationship between microstructure and bone mechanics subjected to in situ mechanical testing. However, it is well known that the effect of SR X-ray radiation can considerably alter the mechanical properties of bone tissue. Digital volume correlation (DVC) has been extensively used to compute full-field strain distributions in bone specimens subjected to step-wise mechanical loading, but tissue damage from sequential SR-microCT scans has not been previously addressed. Therefore, the aim of this study is to examine the influence of SR irradiation-induced microdamage on the apparent elastic properties of trabecular bone using DVC applied to in situ SR-microCT tomograms obtained with different exposure times. Results showed how DVC was able to identify high local strain levels (> 10,000 µε) corresponding to visible microcracks at high irradiation doses (~ 230 kGy), despite the apparent elastic properties remained unaltered. Microcracks were not detected and bone plasticity was preserved for low irradiation doses (~ 33 kGy), although image quality and consequently, DVC performance were reduced. DVC results sugg...Continue Reading

Citations

Feb 28, 2020·BMC Biology·Shelley D RawsonSarah H Cartmell
Jun 13, 2020·Journal of Microscopy·A KaraliG Tozzi
Sep 10, 2020·Materials·Jeffrey N ClarkJonathan R T Jeffers
Feb 6, 2019·Frontiers in Bioengineering and Biotechnology·Sophie Le CannHanna Isaksson
Aug 17, 2020·Scientific Reports·Mikael J TurunenHanna Isaksson
Aug 28, 2020·Frontiers in Bioengineering and Biotechnology·Sophie Le CannHanna Isaksson
May 13, 2019·ACS Biomaterials Science & Engineering·Marta Peña FernándezGianluca Tozzi
Dec 16, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jonathan KusinsLouis M Ferreira

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