Effect of staged ovariectomy on measures of mammary growth and development in prepubertal dairy heifers

Animal : an International Journal of Animal Bioscience
B T VelayudhanR M Akers

Abstract

Previous studies in prepubertal heifers suggest that the magnitude of reduction in mammary parenchymal growth in response to ovariectomy varies with the age at which surgery is performed. We hypothesized that ovarian secretions are essential for initiating mammary development but not required to maintain allometric mammary growth in prepubertal dairy heifers. The objectives of this study were to determine the effect of staged ovariectomy during the prepubertal period on mammary growth and tissue composition and the expression of selected genes. Prepubertal Holstein heifers at 2, 3 or 4 months of age were randomly assigned to one of two treatments, ovariectomized (OVX; n = 12) or sham operated (INT; n = 12). Mammary parenchyma (PAR) and fat pad (MFP) were harvested 30 days after surgery. Proximate composition of PAR and MFP (DNA, protein and lipid) as well as expression of the selected estrogen-responsive genes stanniocalcin1 (STC1), tissue factor pathway inhibitor precursor (TFPI) and proliferating cell nuclear antigen (PCNA) were determined in PAR and MFP by quantitative real-time PCR. The relative amount of epithelium and proportion of epithelia cell nuclei expressing the proliferation marker Ki67 were determined by histologi...Continue Reading

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Citations

Feb 14, 2014·Proceedings. Biological Sciences·N StroeymeytN R Franks
Jan 18, 2005·Journal of Dairy Science·E G BrownM S Weber Nielsen
Aug 8, 2015·Journal of Animal Physiology and Animal Nutrition·F O M FigueiredoI A M A Teixeira
Jul 10, 2019·Animal : an International Journal of Animal Bioscience·A J Geiger
Dec 7, 2020·Journal of Mammary Gland Biology and Neoplasia·Katherine Hughes

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