Effect of statin treatment on circulating malondialdehyde concentrations: a systematic review and meta-analysis

Therapeutic Advances in Chronic Disease
Angelo ZinelluArduino Aleksander Mangoni

Abstract

The effect of statins on oxidative stress markers, such as malondialdehyde (MDA), is still a matter of debate. We sought to address this issue by conducting a systematic review and meta-analysis of published data on the effect of statin treatment on systemic MDA concentrations. A literature search was conducted on MEDLINE/PubMed, ISI Web of Sciences and Scopus. Data were pooled using a random-effects model. A total of 35 studies assessing MDA concentrations before and after statin treatment in 1512 participants (mean age 53.6 years, 48.7% males) were identified. Extreme between-study heterogeneity was observed (I2 = 96.0%, p < 0.001). Pooled standardized mean difference (SMD) showed a significant reduction in plasma MDA concentrations after treatment (SMD = -1.47 µmol/l, 95% confidence interval = -1.89 to -1.05 μmol/l; p < 0.001). Similarly, a subgroup analysis of 10 studies that also included a placebo group showed a significant reduction in plasma MDA concentrations with statins (-1.03 μmol/l, 95% confidence interval = -1.52 to -0.29 μmol/l; p = 0.036). This systematic review and meta-analysis showed that statin treatment significantly reduces systemic MDA concentrations. However, the results should be interpreted with cautio...Continue Reading

References

Apr 6, 1989·The New England Journal of Medicine·D SteinbergJ L Witztum
Jul 21, 1999·Kidney International. Supplement·O NishikawaS Yukawa
Jan 9, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·S H WilsonA Lerman
Sep 29, 2001·Journal of Clinical Epidemiology·J A Sterne, M Egger
Feb 9, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Sven WassmannGeorg Nickenig
Jun 5, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jai Won ChangSoon Bae Kim
Jun 20, 2002·Free Radical Research·M Cristina PolidoriPatrizia Mecocci
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Mar 5, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Sebastian WolfrumJames K Liao
Jun 9, 2004·Hypertension·Kwang Kon KohEak Kyun Shin
Jun 11, 2004·European Journal of Pharmacology·Jan SkrhaRichard Ceska
Oct 19, 2004·European Journal of Clinical Pharmacology·Mariann HarangiEva Remenyik
Apr 30, 2005·International Journal of Cardiology·Emmanouil KaratzisMyron Mavrikakis
Mar 28, 2006·Biochemical and Biophysical Research Communications·Mark HsuDavid K Stevenson
Jun 2, 2006·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Angela MolcányiováIvan Tkác
Jan 16, 2007·Journal of Cardiovascular Pharmacology and Therapeutics·Vipul SaveGirish Rajadhyaksha
Oct 4, 2007·Annals of the New York Academy of Sciences·Anna Abou-RayaMadihah Helmii
Apr 1, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Pablo F CastroSergio Lavandero
Jun 26, 2009·Journal of Diabetes and Its Complications·Amany A AbdinSaad El-Din A Abou El-Noeman
Nov 12, 2009·Pharmacological Reports : PR·Amar NagilaSureerut Porntadavity
Apr 29, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Qian Zhou, James K Liao
Nov 3, 2010·The Journal of Rheumatology·Amal M El-BarbaryRaghda G Ismail
Jun 21, 2011·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Waleed Samy, Mohammed A Hassanian
Jan 24, 2012·Journal of Clinical Lipidology·Jonathan R MurrowArshed A Quyyumi
Aug 11, 2012·The Journal of Clinical Endocrinology and Metabolism·Thozhukat SathyapalanStephen L Atkin
Jun 6, 2013·Nature Reviews. Cardiology·Željko Reiner
Jul 24, 2013·Nitric Oxide : Biology and Chemistry·V L AndradeV C Sandrim
Aug 13, 2013·Mediators of Inflammation·Angela PirilloAlberico Luigi Catapano
Nov 14, 2013·Mediators of Inflammation·Giuseppe MaiolinoLorenzo A Calò

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Citations

May 28, 2020·Retina·Antonio PinnaAngelo Zinellu
Jan 14, 2021·Canadian Journal of Physiology and Pharmacology·Branislav KuraJan Slezak

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Methods Mentioned

BETA
MDA
enzyme-linked immunosorbent

Software Mentioned

Scopus
Stata
MedCalc
MS Excel

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