PMID: 9646327Jul 1, 1998Paper

Effect of stem cell factor, interleukin-6, nitric oxide and transforming growth factor-beta on the osteoclast differentiation induced by 1 alpha,25-(OH)2D3 in primary murine bone marrow cultures

Pharmacology & Toxicology
H J ChaeH R Kim

Abstract

Osteotropic hormones and cytokines are involved in the differentiation of osteoclast progenitors from haematopoietic stem cells to multinucleated osteoclasts which mediate bone resorption. Stem cell factor, interleukin-6, nitric oxide, and transforming growth factor-beta are implicated in the regulation of bone resorption by osteoclast. We test whether stem cell factor, interleukin-6, nitric oxide, and transforming growth factor-beta affect the generation of osteoclast-like multi-nucleated cells induced by 1 alpha,25-(OH)2D3. 1 alpha,25-(OH)2D3 increase the generation of osteoclast-like cells retaining osteoclast characteristics including multinuclearity and positive staining for tartrate-resistant acid phosphatase. Combined treatment of stem cell factor with interleukin-6 synergistically potentiates the ability of 1 alpha,25-(OH)2D3 to generate tartrate-resistant acid phosphatase-positive multinucleated cells. However, either stem cell factor or interleukin-6 alone does not induce the generation of tartrate-resistant acid phosphatase-positive multinucleated cells. Transforming growth factor-beta produces a biphasic effect on osteoclast generation induced by 1 alpha,25-(OH)2D3. Transforming growth factor-beta stimulates osteocl...Continue Reading

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Citations

Nov 6, 2009·Blood·Kate VandykeAndrew C W Zannettino
Oct 3, 2015·International Immunopharmacology·Jinhee KimGwi Seo Hwang
Aug 16, 2001·Critical Reviews in Toxicology·E J Calabrese, L A Baldwin
Aug 16, 2001·Critical Reviews in Toxicology·E J Calabrese
Mar 3, 2020·Frontiers in Immunology·Deniz RagipogluVerena Fischer
Oct 13, 2012·Human & Experimental Toxicology·E J CalabreseV Calabrese

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