Effect of Stem Cell Therapy on Bone Mineral Density: A Meta-Analysis of Preclinical Studies in Animal Models of Osteoporosis

PloS One
Feng LiQun Gu

Abstract

Preclinical studies of the therapeutic role of stem cell based therapy in animal models of osteoporosis have largely yielded inconsistent results. We performed a meta-analysis to provide an overview of the currently available evidence. Pubmed, Embase and Cochrane Library databases were systematically searched for relevant controlled studies. A random-effect model was used for pooled analysis of the effect of stem cell based therapy on bone mineral density (BMD). Stratified analyses were performed to explore the effect of study characteristics on the outcomes. Pooled results from 12 preclinical studies (110 animals in stem cell treatment groups, and 106 animals in control groups) indicated that stem cell based treatment was associated with significantly improved BMD (standardized mean difference [SMD] = 1.29, 95% Confidence Interval [CI]: 0.84-1.74, P < 0.001) with moderate heterogeneity (Cochrane's Q test: P = 0.02, I2 = 45%) among the constituent studies. Implantation of bone marrow cells, bone marrow mesenchymal stem cells, adipose-derived stem cells, and human umbilical cord blood-derived CD34+ cells, were all associated with improved BMD as compared to that in the controls (P < 0.05 for all); the only exception being the us...Continue Reading

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Citations

Apr 5, 2017·Expert Opinion on Biological Therapy·Marta BarbaWanda Lattanzi
Sep 12, 2019·Annual Review of Medicine·Cheng ChengDolores M Shoback
Nov 7, 2019·International Journal of Molecular Sciences·Dalia MedhatArantza Infante
Jul 29, 2020·Frontiers in Endocrinology·Babak ArjmandBagher Larijani
Jul 10, 2019·Stem Cells International·Vasilis Paspaliaris, George Kolios
Oct 21, 2020·International Journal of Molecular Sciences·Ji-Yoon NohHaiyoung Jung

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