Effect of stem cell transplantation of premature ovarian failure in animal models and patients: A meta-analysis and case report

Experimental and Therapeutic Medicine
Lei ChenYan Xu

Abstract

Stem cell transplantation has been considered a promising therapeutic approach for premature ovarian failure (POF). However, to date, no quantitative data analysis of stem cell therapy for POF has been performed. Therefore, the present study performed a meta-analysis to assess the efficacy of stem cell transplantation in improving ovarian function in animal models of POF. In addition, a case report of a patient with POF subjected to stem cell treatment was included to demonstrate that stem cell therapy also contributes to the recovery of ovarian function in patients. Published studies were identified by a systematic review of the PubMed, Embase, and Cochrane's library databases, and references cited in associated reviews were also considered. Data regarding follicle-stimulating hormone (FSH), estradiol (E2), ovarian weight, follicle count, the number of pregnancies and other parameters, including delivery route and cell type, were extracted. Pooled analysis, sensitivity analyses, subgroup analyses and meta-regression were performed. In the case of POF, transvaginal ultrasound (TVS), abdominal ultrasound (TAS) and color Doppler flow imaging (CDFI) were performed to observe the endometrial morphology and blood flow signals in the...Continue Reading

Citations

Oct 31, 2019·Journal of Cellular Physiology·Maryam Ghahremani-NasabMehdi Yousefi
Sep 22, 2020·World Journal of Stem Cells·Khadijeh BahrehbarHossein Baharvand
Oct 15, 2020·Cells·Sahar EsfandyariAyman Al-Hendy
Mar 7, 2021·International Journal of Molecular Sciences·Sahar EsfandyariAyman Al-Hendy
Jul 18, 2021·Human Cell·Guanwen GaoXiao Zhu

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Methods Mentioned

BETA
hormone
hormone replacement therapy

Software Mentioned

Stata
CDFI

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