Effect of Steroid Elution on Electrical Performance and Tissue Responses in Quadripolar Left Ventricular Cardiac Vein Leads

Pacing and Clinical Electrophysiology : PACE
Zhongping YangRick McVenes

Abstract

The use of steroid elution (SE) electrode in a cardiac pacing lead is known to suppress myocardial inflammation to lower pacing thresholds (PTs). SE has been widely utilized on the distal electrode of left ventricular cardiac vein (LVCV) leads used in cardiac resynchronization therapy (CRT). However, no paired comparison in effect of SE has been studied in proximal electrodes of quadripolar LVCV leads. We evaluated electrical performance and tissue responses of quadripolar LVCV lead electrodes with and without SE in two canine studies with a total of 14 canines. Extended bipolar PT and pacing impedance of the LVCV electrodes to right ventricle coil were collected via an implantable CRT device/programmer or a percutaneous threshold analyzer/pacing analyzer at weeks 0, 1, 2, 4, 6, 8, and 12. Gross and histopathological examinations of the canines were performed at the end of the studies. Our preclinical studies showed that SE had significant effects on the long-term pacing performance of quadripolar LVCV leads. The SE tip and ring electrodes reduced postimplant PT peak and chronic PT, P = 0.038. Histological examination of the perilead tissue capsules at 12 weeks showed a reduced thickness for the location of SE electrodes. SE el...Continue Reading

References

Jan 1, 1992·Pacing and Clinical Electrophysiology : PACE·H G Mond, K B Stokes
Jul 1, 1996·Pacing and Clinical Electrophysiology : PACE·H G Mond, K B Stokes
Jan 5, 2001·Pacing and Clinical Electrophysiology : PACE·M AchtelikUNKNOWN VENTAK CHF/CONTAK CD Clinical Investigation Study Group
Aug 14, 2003·Pacing and Clinical Electrophysiology : PACE·M Silvana HorensteinPeter P Karpawich
Apr 11, 2006·British Journal of Pharmacology·Peter J Barnes
Sep 2, 2009·Pacing and Clinical Electrophysiology : PACE·Grace LinPeter A Brady
Dec 5, 2009·Circulation Research·Colby A SoudersTroy A Baudino
Oct 14, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Johannes SperzelChristopher A Rinaldi
Aug 19, 2014·Pacing and Clinical Electrophysiology : PACE·Harry G MondRick McVenes

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Citations

Dec 13, 2016·Pacing and Clinical Electrophysiology : PACE·Ernest W Lau
Aug 25, 2017·Expert Review of Medical Devices·Antonios P AntoniadisChristopher A Rinaldi
Aug 1, 2015·JACC. Clinical Electrophysiology·Wouter M van EverdingenMathias Meine

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