PMID: 6974862May 1, 1981Paper

Effect of steroid hormones on DNA matrix activity and glucocorticoid-receptor interaction

Problemy e̊ndokrinologii
P P Golikov, A S Bobkova

Abstract

The effect of 22 steroids on the matrix DNA activity was studied on thymocyte suspension of adrenalectomized Wistar male rats (80 to 100 g body weight) by means of 3H-uridine incorporation into acid-undissolved RNA fraction and 3H-triamcinolone acetonide-receptor interaction in thymocyte cytosol. Inhibiting effect of natural hormones on the labelled uridine incorporation into thymocyte RNA decreased as follows: dehydrocortisone greater than progesterone greater than pregnanediol greater than aldosterone greater than pregnenolone greater than 11-DOC greater than cortexolone greater than methyltestosterone greater than cortisone greater than 17 alpha-hydroxyprogesterone greater than androsterone greater than estradiol greater than aldactone greater than testosterone greater than pregnanetriol. All the steroids exerted an additive action on the glucocorticoid effect, with the exception of cortexolone, possessing antiglucocorticoid effect, and 11-DOC which did not influence dexamethasone glucocorticoid action. Almost all the steroids inhibiting 3H-uridine incorporation into RNA, competed actively with triamcinolone acetonide, concerning thymocyte cytosol binding with glucocorticoid receptor.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved