Effect of stimulation frequency on tremor suppression in essential tremor

Movement Disorders : Official Journal of the Movement Disorder Society
Mwiza UsheJoel S Perlmutter

Abstract

We sought to determine the effect of deep brain stimulation (DBS) frequency on tremor suppression in essential tremor (ET) patients with deep brain stimulators implanted in the ventral intermediate nucleus (VIM) of the thalamus. A uniaxial accelerometer was used to measure tremor in the right upper extremity of subjects with a diagnosis of ET who had DBS electrodes implanted in the left VIM. The root-mean-square acceleration was used as the index of tremor magnitude and normalized to the OFF DBS condition. There was a highly significant inverse sigmoidal relationship between stimulation frequency and normalized tremor acceleration (X(2)/DoF = 0.42, r(2) = 0.997). Tremor acceleration had a nearly linear response to stimulation frequencies between 45 and 100 Hz with little additional benefit above 100 Hz. These findings have two important implications. Clinically, frequency of thalamic stimulation is an important variable for optimal tremor control with maximal benefit achieved with 100 to 130 Hz in most patients. Second, thalamic DBS provides tremor benefit in a graded manner and is not an all-or-nothing phenomenon.

References

Feb 1, 1986·Neurology·R J Elble
Sep 26, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·A StrafellaA E Lang
Nov 25, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·A L BenabidP Pollak
Feb 17, 2000·The New England Journal of Medicine·P R SchuurmanJ D Speelman
Apr 12, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Jonathan O Dostrovsky, Andres M Lozano
Apr 12, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Jerrold L Vitek
Apr 12, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Alim L BenabidPierre Pollak
May 16, 2002·Neurology·J S PerlmutterT O Videen
Mar 12, 2003·Neurology·Padraig E O'SuilleabhainRichard B Dewey

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Citations

Jan 1, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Merrill J Birdno, Warren M Grill
Sep 16, 2008·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Scott E CooperWarren M Grill
Apr 5, 2008·Neuroreport·Merrill J BirdnoWarren M Grill
Jun 17, 2006·Annual Review of Neuroscience·Joel S Perlmutter, Jonathan W Mink
Oct 14, 2011·Journal of Neurophysiology·Merrill J BirdnoWarren M Grill
Mar 15, 2005·The Journal of Clinical Investigation·Joseph Jankovic, Jeffrey L Noebels
May 9, 2014·PloS One·Merrill J BirdnoWarren M Grill
Aug 29, 2014·Surgical Neurology International·Damián BenderskyClaudio Yampolsky
Oct 9, 2007·Experimental Neurology·Gammon M EarhartJoel S Perlmutter
Mar 26, 2016·Frontiers in Computational Neuroscience·João Couto, Warren M Grill
Nov 14, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Gammon M EarhartJoel S Perlmutter
Jul 3, 2007·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Alexis M KuncelWarren M Grill
Mar 31, 2016·Neuroscience and Biobehavioral Reviews·D C W KloosterP Boon
Jun 9, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Dietrich HaubenbergerRodger J Elble
Aug 9, 2016·Parkinsonism & Related Disorders·José Fidel Baizabal-Carvallo, Marlene Alonso-Juarez
Sep 16, 2008·Neurosurgery·Ali R RezaiNicholas M Boulis
Jun 13, 2018·Journal of Neural Engineering·Guosheng Yi, Warren M Grill
May 11, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Mwiza UsheJoel S Perlmutter
Sep 15, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Alexis M KuncelWarren M Grill
Mar 31, 2007·Physiological Measurement·Mario MantoStephane Camut
Sep 24, 2020·Journal of Neurophysiology·Edward M BelloMatthew D Johnson

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Movement Disorders : Official Journal of the Movement Disorder Society
Mwiza UsheJoel S Perlmutter
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Alexis M KuncelWarren M Grill
Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
Merrill J Birdno, Warren M Grill
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