Effect of Stimulation Waveform on the Non-linear Entrainment of Cortical Alpha Oscillations

Frontiers in Neuroscience
Axel HuttJérémie Lefebvre

Abstract

In the past decade, there has been a surge of interest in using patterned brain stimulation to manipulate cortical oscillations, in both experimental and clinical settings. But the relationship between stimulation waveform and its impact on ongoing oscillations remains poorly understood and severely restrains the development of new paradigms. To address some aspects of this intricate problem, we combine computational and mathematical approaches, providing new insights into the influence of waveform of both low and high-frequency stimuli on synchronous neural activity. Using a cellular-based cortical microcircuit network model, we performed numerical simulations to test the influence of different waveforms on ongoing alpha oscillations, and derived a mean-field description of stimulation-driven dynamics to better understand the observed responses. Our analysis shows that high-frequency periodic stimulation translates into an effective transformation of the neurons' response function, leading to waveform-dependent changes in oscillatory dynamics and resting state activity. Moreover, we found that randomly fluctuating stimulation linearizes the neuron response function while constant input moves its activation threshold. Taken tog...Continue Reading

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Citations

Oct 10, 2018·Frontiers in Neuroscience·Min D Tang-SchomerSabato Santaniello
Jun 6, 2021·Brain Topography·Matteo SaponatiAlberto Mazzoni

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