Effect of stimulus size and luminance on the rod-, cone-, and melanopsin-mediated pupillary light reflex

Journal of Vision
Jason C Park, J Jason McAnany

Abstract

This study determined if the pupillary light reflex (PLR) driven by brief stimulus presentations can be accounted for by the product of stimulus luminance and area (i.e., corneal flux density, CFD) under conditions biased toward the rod, cone, and melanopsin pathways. Five visually normal subjects participated in the study. Stimuli consisted of 1-s short- and long-wavelength flashes that spanned a large range of luminance and angular subtense. The stimuli were presented in the central visual field in the dark (rod and melanopsin conditions) and against a rod-suppressing short-wavelength background (cone condition). Rod- and cone-mediated PLRs were measured at the maximum constriction after stimulus onset whereas the melanopsin-mediated PLR was measured 5-7 s after stimulus offset. The rod- and melanopsin-mediated PLRs were well accounted for by CFD, such that doubling the stimulus luminance had the same effect on the PLR as doubling the stimulus area. Melanopsin-mediated PLRs were elicited only by short-wavelength, large (>16°) stimuli with luminance greater than 10 cd/m(2), but when present, the melanopsin-mediated PLR was well accounted for by CFD. In contrast, CFD could not account for the cone-mediated PLR because the PLR w...Continue Reading

Citations

Oct 25, 2016·Journal of Neuroscience Methods·Mark BushnellEduardo Solessio
Mar 24, 2017·Scientific Reports·Jason C ParkJ Jason McAnany
Mar 14, 2018·Diagnostics·Charlotte A Hall, Robert P Chilcott
Oct 17, 2018·Investigative Ophthalmology & Visual Science·Marija ZivcevskaAgnes M F Wong
Nov 16, 2017·Documenta Ophthalmologica. Advances in Ophthalmology·Jason C ParkJ Jason McAnany
Apr 2, 2016·Documenta Ophthalmologica. Advances in Ophthalmology·Frederick T CollisonJ Jason McAnany
Jun 25, 2020·Investigative Ophthalmology & Visual Science·J Jason McAnanyFrederick T Collison
Dec 24, 2018·Investigative Ophthalmology & Visual Science·Soad Haj YahiaYgal Rotenstreich
Mar 31, 2019·Documenta Ophthalmologica. Advances in Ophthalmology·Frederick T CollisonJ Jason McAnany
Mar 3, 2020·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Kei Kanari
May 14, 2020·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Neil R A ParryIan J Murray
Sep 4, 2020·Translational Vision Science & Technology·Jason C ParkJ Jason McAnany
Mar 15, 2016·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Kavita VemuriSrinivasa Varadharajan
Mar 12, 2019·Frontiers in Neurology·Carina KelbschBarbara J Wilhelm
Apr 1, 2018·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Ian J MurrayNeil R A Parry
Apr 8, 2021·Journal of Biomedical Informatics·Hedenir Monteiro Pinheiro, Ronaldo Martins da Costa
May 7, 2021·Scientific Reports·Corinne KosticAki Kawasaki

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