Effect of Stimulus Waveform of Biphasic Current Pulse on Retinal Ganglion Cell Responses in Retinal Degeneration (rd1) mice

The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology
Kun No AhnYong Sook Goo

Abstract

A retinal prosthesis is being developed for the restoration of vision in patients with retinitis pigmentosa (RP) and age-related macular degeneration (AMD). Determining optimal electrical stimulation parameters for the prosthesis is one of the most important elements for the development of a viable retinal prosthesis. Here, we investigated the effects of different charge-balanced biphasic pulses with regard to their effectiveness in evoking retinal ganglion cell (RGC) responses. Retinal degeneration (rd1) mice were used (n=17). From the ex-vivo retinal preparation, retinal patches were placed ganglion cell layer down onto an 8×8 multielectrode array (MEA) and RGC responses were recorded while applying electrical stimuli. For asymmetric pulses, 1st phase of the pulse is the same with symmetric pulse but the amplitude of 2nd phase of the pulse is less than 10 µA and charge balanced condition is satisfied by lengthening the duration of the pulse. For intensities (or duration) modulation, duration (or amplitude) of the pulse was fixed to 500 µs (30 µA), changing the intensities (or duration) from 2 to 60 µA (60 to 1000 µs). RGCs were classified as response-positive when PSTH showed multiple (3~4) peaks within 400 ms post stimulus a...Continue Reading

Citations

Dec 22, 2017·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Parichehr HassanzadehMeshkat Dinarvand
Jun 8, 2018·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Kyle LoizosGianluca Lazzi
Jul 30, 2019·Journal of Neural Engineering·Hee Won SeoSohee Kim
Sep 9, 2017·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Jungryul AhnYongsook Goo
Mar 4, 2020·Experimental Neurobiology·Jungryul AhnYong Sook Goo
Jan 4, 2017·Journal of Neural Engineering·Myoung-Hwan ChoiYong Sook Goo
Jun 27, 2020·Journal of Neural Engineering·Dorsa Haji GhaffariJames D Weiland
Sep 15, 2020·Experimental Neurobiology·Jungryul AhnYong Sook Goo

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