PMID: 6159845May 1, 1980Paper

Effect of stress and sampling site on metabolite concentration in rat plasma

Archives internationales de physiologie et de biochimie
L ArolaM Alemany

Abstract

The effect of mild stress on various plasma metabolites in the rat has been studied. Mild stress resulted in significant decreases in liver size and glycogen content, as well as in an increase of blood glucose. In addition, plasma lactate, insulin, glycerol and urea, as well as a number of amino acids were altered by stress. These data indicate that minimal stress can have major effects upon the composition of blood, and suggest the need for strict precautions on the handling of animals during blood sampling. The site of blood extraction--tail tip vs. neck--was also found to have a significant effect on plasma lactate, glucose and urea concentrations. In stressed animals the differences between tail- and neck blood composition were increased.

References

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Citations

Jul 1, 1989·European Journal of Drug Metabolism and Pharmacokinetics·S H Akrawi, P J Wedlund
Jan 1, 1985·The International Journal of Biochemistry·F J López-SorianoJ M Argilés
Feb 25, 1985·Life Sciences·L MilakofskyW H Vogel
Apr 1, 1989·Pharmacology, Biochemistry, and Behavior·L MilakofskyW H Vogel
Mar 15, 2011·The Journal of Pharmacology and Experimental Therapeutics·Siddharth SukumaranRichard R Almon
Jan 1, 2012·Molecular Metabolism·Maximilian BielohubyMartin Bidlingmaier
Nov 1, 1984·Archives internationales de physiologie et de biochimie·L ArolaM Alemany
Jan 1, 1982·Annals of the New York Academy of Sciences·P M Sinet
Sep 29, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ryan A FrielerThad A Rosenberger

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