PMID: 7026327May 1, 1981Paper

Effect of strict blood glucose control on residual B-cell function in insulin-dependent diabetics

Diabetologia
S MadsbadC Binder

Abstract

In 14 insulin dependent diabetics past their initial remission period B-cell function was evaluated using a test meal before and after 1 week of strict blood glucose control, and again 3 weeks later when the patients were outpatients on conventional therapy. Eight patients with fasting C-peptide above 0.07 nmol/l improved their B-cell function significantly (p Less Than 0.05) during the period of strict blood glucose control. However, the improvement was of short duration and was absent 3 weeks later in most patients. Six patients with fasting C-peptide below or equal to 0.07 nmol/l had no significant improvement in B-cell function during the period of strict control. The study shows that B-cell function and degree of blood glucose control are related in patients with fasting C-peptide above 0.07 nmol/l, and that B-cell function can change within days.

Citations

Feb 27, 2009·Diabetes Care·Lene Ringholm NielsenElisabeth R Mathiesen
Mar 1, 1981·The American Journal of Medicine·M A PfeiferD Porte
Jun 1, 1987·Acta Paediatrica Japonica; Overseas Edition·B Weber, M Hasala
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May 15, 2003·Diabetes & Metabolism·P Home

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