Effect of strontium doping on the biocompatibility of calcium phosphate-coated titanium substrates

Journal of Applied Biomaterials & Functional Materials
Thuy-Duong Thi NguyenTae-Sung Bae

Abstract

Titanium biomedical devices coated with strontium-doped calcium phosphate ceramics can support desirable bone regeneration through anabolic and anti-catabolic effects of strontium and the compositions close to that of natural mineral tissue. Strontium was doped into the calcium phosphate coating using the cyclic pre-calcification method on the anodized titanium plate. The effects of the different concentration of strontium in treatment solution and cycle numbers of the pre-calcification treatment on the biocompatibility were investigated in terms of the changes in morphology and chemical composition of coating, ion release pattern and cytocompatibility in vitro. At a high substitution ratio of strontium in the calcium phosphate coating, the size of precipitated particles was decreased and the solubility of the coating was increased. ASH55 group, which was coated by pre-calcification treatment of 20 cycles in coating solution with Sr:Ca molar ratio of 5:5, exhibited superior cellular attachment at 1 day and proliferation after 7 days of culturing in comparison with the non-doped surface and other doped surfaces. Sufficient strontium doping concentrations in calcium phosphate coating can enhance cell adhesion and proliferation on...Continue Reading

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Citations

Sep 1, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yang-Yang ZhangMeng-Chun Qi
Feb 18, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Daniel Arcos, María Vallet-Regí
Dec 9, 2019·ACS Biomaterials Science & Engineering·Thuy-Duong Thi NguyenTae-Sung Bae

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Methods Mentioned

BETA
scanning
X-ray
scanning electron microscopy
fluorescence microscopy

Software Mentioned

SPSS

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