Effect of subchronic exposure to malathion on glycogen phosphorylase and hexokinase activities in rat liver using native PAGE

Toxicology
Raja RezgNajoua Gharbi

Abstract

The aim of this study was the evaluation of the effects of a subchronic exposure to malathion, an organophosphorus (OP) insecticide, on plasma glucose and hepatic enzymes of glycogenolysis and glycolysis in rats in vivo. Malathion was administered intragastrically by stomach tube in the amount of 1 ml corn oil containing 100mg/kg body weight (BW) daily for 32 days. At the end of the experiment, the liver was removed. The activities of glycogen phosphorylase (GP) and hexokinase (HK) were analysed in the homogenate. The methodology employed was a non-denaturing electrophoresis followed by activity-staining (native PAGE). Malathion decrease GP activity by 50% and increase HK activity by 10%. In addition, an hepatomegaly was recorded with a rise in the hepatic glycogen rate in malathion-treated rats. Moreover, subchronic administration of malathion has no effect on blood glucose concentration. The storage of glycogen in liver may be due to a stimulation of insulin secretion after the inhibition of acethylcholinesterase activity in pancreatic beta cells by malathion. These findings were in favour of an activation of glycogen storage by malathion.

References

Feb 1, 1979·Annals of Surgery·T D DresselJ W Borner
Aug 1, 1975·Canadian Journal of Zoology·A L ArsenaultM E Mader
Jan 1, 1992·Forensic Science International : Synergy·R K JadhavH Chandra
Jun 1, 1987·Biochemical Pharmacology·M A Matin, K Husain
Oct 1, 1986·Ecotoxicology and Environmental Safety·M A RodriguesM T Mazanti
Oct 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·H M Katzen, R T Schimke
May 15, 1983·Experientia·H J BöhmeE Hofmann
Jan 1, 1994·Intensive Care Medicine·F MoritzJ Leroy
Dec 31, 1997·Journal of Clinical Gastroenterology·E PanieriD M Linton
Jan 5, 2001·Pharmacology & Toxicology·M C YangD G Le Couteur
Sep 7, 2002·Journal of Toxicology. Clinical Toxicology·Yüksel GokelAyca Acikalin
Jul 2, 2004·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Mohammad AbdollahiMaryam Saadat
Jan 1, 2005·Environmental Toxicology and Pharmacology·Shirin PournourmohammadiMohammad Abdollahi

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Citations

May 20, 2014·Ecotoxicology and Environmental Safety·Ahmed Th A Ibrahim, Ahmed S A Harabawy
Sep 30, 2008·Pakistan Journal of Biological Sciences : PJBS·Goudarz Sadeghi-HashjinShahram Javadi
Jun 1, 2012·Pakistan Journal of Biological Sciences : PJBS·Siti Balkis BudinIzatus Shima Taib
Jan 22, 2013·Environmental Toxicology and Pharmacology·Eman E ElsharkawyNeveen A El-Nisr
Feb 17, 2007·Comptes rendus biologies·Raja RezgNajoua Gharbi
Aug 14, 2012·Journal of Applied Toxicology : JAT·Syed M NurulainErnest Adeghate
Jul 15, 2015·Environmental Science and Pollution Research International·Imen Flehi-SlimHassen Ben Cheikh
Nov 19, 2014·Environmental Science and Pollution Research International·Raja RezgNajoua Gharbi
Mar 18, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Raja RezgNajoua Gharbi
Jan 18, 2018·Arhiv za higijenu rada i toksikologiju·Somayyeh Karami-MohajeriMohammad Abdollahi
Dec 14, 2017·Environmental Science and Pollution Research International·Marco Antonio Ramirez-VargasMa Elena Moreno-Godinez
Jan 28, 2020·The Journal of Veterinary Medical Science·Kanoko OnaruNobuhiko Hoshi
Nov 17, 2020·Frontiers in Public Health·Mbah Ntepe Leonel JaveresSyed Muhammed Nurulain
Mar 4, 2021·International Journal of Environmental Research and Public Health·Mbah Ntepe Leonel JaveresSyed Muhammad Nurulain
Sep 8, 2018·Journal of Agricultural and Food Chemistry·Jason S Yang, Yeonhwa Park

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