Abstract
Staphylococcus epidermidis is the preeminent cause of nosocomial bacteraemia and infection of prosthetic medical devices. Bacterial adherence to biomaterial is a crucial early event in the pathogenesis of these infections. Antibiotics affect bacterial adherence to eukaryotic cells, capsule formation and biofilm production. However, results from studies involving coagulase-negative staphylococci are equivocal. In this study, the in-vitro adherence of radiolabelled bacteria was assayed to determine the effect of sublethal concentrations of a number of antibiotics on the attachment of four strains of S. epidermidis, with well-characterized adherence profiles, to intravascular catheters. The effect of antibiotics on biofilm production by S. epidermidis was assayed using a quantitative spectrophotometric assay. Although there was some strain-to-strain variability, none of the tested antibiotics affected bacterial attachment. However, treatment with cefazolin or vancomycin resulted in a significant decrease in biofilm elaboration. These data suggest that bacterial attachment by S. epidermidis, the initiating event associated with prosthetic device infection, cannot be prevented by subtherapeutic levels of fluoroquinolone, glycopeptid...Continue Reading
Citations
May 29, 2004·International Journal of Antimicrobial Agents·Paul J PaganoJohn K Gibson
Jul 21, 2001·International Journal of Antimicrobial Agents·A A KadryA M Shibl
Mar 4, 1999·Journal of Applied Microbiology·C J LintonM R Millar
Jan 17, 2009·The Journal of Antimicrobial Chemotherapy·Ashraf A KadryAhmed A Abu El-Asrar
Nov 18, 2000·Antimicrobial Agents and Chemotherapy·S RachidW Ziebuhr
Oct 16, 2001·Antimicrobial Agents and Chemotherapy·R E PolonioJ F Sperry
Oct 25, 2003·Antimicrobial Agents and Chemotherapy·Julie A WuJohn F Kokai-Kun
May 28, 2010·Annals of Clinical Microbiology and Antimicrobials·Yue QuMargaret A Deighton
Mar 16, 2013·Infection and Drug Resistance·Majed M MasadehEsra'a I Al-Trad
Jan 13, 2015·Journal of Proteomics·Yu-Lin ZhaoYan-Hua Li
Nov 28, 2015·Sensors·Katarína MlynárikováVeronika Holá
Mar 16, 2011·Research in Microbiology·Jeffrey B KaplanIrina Sadovskaya
Oct 9, 2015·Archives of Microbiology·Yan-Bei YangYan-Hua Li
Oct 16, 2004·Letters in Applied Microbiology·N CercaJ Azeredo
Mar 13, 2003·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jürgen PinocyGerhard Ziemer
Oct 23, 2010·Journal of Basic Microbiology·Zulfiqar Ali Mirani, Nusrat Jamil
Jul 20, 2011·Letters in Applied Microbiology·P JiaS H Shao
Sep 26, 2009·Journal of Applied Microbiology·R N S HaddadinP J Collier
Apr 12, 2016·Frontiers in Microbiology·Shuai WangYanhua Li
Jul 8, 2017·Future Microbiology·Katarína RebrošováVeronika Holá
Jun 15, 2001·Phytotherapy Research : PTR·S Pérez GR M Pérez G
Aug 20, 2014·Antimicrobial Agents and Chemotherapy·Uyen T NguyenLori L Burrows
Apr 27, 2019·Future Microbiology·Katarína RebrošováVeronika Holá
Jun 8, 2006·The Journal of Bone and Joint Surgery. American Volume·Mete MecikogluTanil Esemenli
Aug 12, 2010·The Journal of Nervous and Mental Disease·Kikuko CampbellHaiyi Xie
Aug 18, 2004·Journal of Medical Microbiology·A P FonsecaJ C Sousa
Nov 19, 2011·The International Journal of Artificial Organs·Jeffrey B Kaplan
Nov 25, 2019·Molecular Biology Reports·Jasleen KaurAmarjeet Kaur
Nov 3, 2017·Scientific Reports·Katarína RebrošováPetr Petráš
Nov 3, 2017·The Bone & Joint Journal·P WahlF Livio