Effect of submicron and nano-iron oxide particles on pulmonary immunity in mice

Toxicology Letters
Masarin BanMichèle Goutet

Abstract

Due to advances in nanotechnology, exposure to particle compounds in the workplace has become unavoidable. Assessment of their toxicity on health is an important occupational safety issue. This study was conducted in mice to investigate the toxicological effects of submicron and nano-iron oxide particles on pulmonary immune defences. In that purpose, we explored for the first time, inflammatory and immune responses in lung-associated lymph nodes. For each particle type, mice received either a single intratracheal instillation at different concentrations (250, 375, or 500μg/mouse) or four repeated instillations at 500μg/mouse each. Cytokine production, inflammatory and innate immune response, and humoral immune response were respectively assessed 1, 2, and 6 days after particle exposures. Both types of particles induced lung inflammation associated with increased cytokine productions in lymph node cell cultures and decreased pulmonary immune responses against sheep erythrocytes. Natural killer activity was not modified by particles. In comparison to single instillation, repeated instillations resulted in a reduction of inflammatory cell numbers in both bronchoalveolar lavages and pulmonary parenchyma. Moreover, the single instil...Continue Reading

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Citations

Jul 17, 2015·Clinical and Molecular Allergy : CMA·Claudia PetrarcaMario Di Gioacchino
Nov 14, 2012·Toxicology Letters·Masarin BanMichèle Goutet
Jun 21, 2014·BioMed Research International·Qing JiaoQiu Zhang
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Saeedeh Najafi-HajivarHadi Valizadeh
Nov 7, 2016·Particle and Fibre Toxicology·Jo Anne Shatkin, Günter Oberdörster
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Feb 29, 2020·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Jody MorganAlison L Jones
Nov 22, 2018·Particle and Fibre Toxicology·Tuang Yeow PohSanjay Haresh Chotirmall
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Jan 20, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Maryam BehzadiNavid Nezafat

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