Effect of substance P and capsaicin on stomach fundus and ileum of streptozotocin-diabetic rats

European Journal of Pharmacology
C PinnaL Puglisi

Abstract

The in vitro responses of longitudinal preparations of rat stomach fundus and ileum to capsaicin at 1, 8, 4, 16 and 26 weeks and to substance P at 1 and 8 weeks from diabetes induction were studied. The results were compared with those obtained in age-matched control rats. The contractile responses to exogenous substance P and capsaicin were not affected in the stomach fundus from diabetic rats. Atropine (1 microM) did not antagonize the substance P-induced response whereas it inhibited about 90% of the capsaicin-induced response in controls and about 60% of the response in diabetic rats. At the resting tone, capsaicin induced a relaxation followed by a contraction in stomach fundus of control rats. Only a contraction was evoked in diabetic rats. In carbachol (0.05-0.1 microM) pre-stimulated strips, a complete restoration of the biphasic response was obtained in the diabetic state. The contractile response elicited by exogenous substance P was not significantly increased in the ileum preparations from diabetic rats; nevertheless the EC50 value for substance P was reduced 8 weeks after the onset of diabetes. The response elicited by capsaicin in the ileum of control rats was also biphasic. The capsaicin-induced contraction was g...Continue Reading

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Citations

Jun 5, 2003·European Journal of Pharmacology·Chusri TalubmookMike Parsons
Jan 1, 1997·Pharmacology & Therapeutics·P Holzer, U Holzer-Petsche
May 5, 2020·Canadian Journal of Physiology and Pharmacology·Jing ZhangShouliang Dong

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