Effect of substance P on CCK- or VIP-induced choleresis in anesthetized dogs

Acta Physiologica Scandinavica
I Magnusson, L Thulin

Abstract

10 anesthetized dogs were provided with acute common bile duct fistulas and the gallbladder was excluded. Hepatic bile output and biliary content of sodium, potassium and amylase were studied. 6 caval infusions were administered of CCK, 0.3 Ivy U.kg-1.min-1, with a superimposed infusion of SP, 20 ng.kg-1.min-1. 7 caval infusions were given of VIP, 50 ng.kg-1.min-1, with a superimposed infusion of SP, 20 ng. kg-1.min-1. CCK increased bile output and biliary content of sodium, potassium and amylase by 78-110%. The corresponding increase induced by VIP was 55-85%. Biliary pH was not influenced. SP abolished the effects of both CCK and VIP. It is suggested that all peptides studied influenced canalicular bile secretion by changing the electrolyte excretion.

References

Jan 1, 1989·Pharmacology & Therapeutics·J Fahrenkrug
Jan 1, 1992·European Journal of Clinical Investigation·B NybergK Einarsson
May 1, 2001·Seminars in Pediatric Surgery·D H Teitelbaum, T Tracy
May 4, 2005·Journal of Pediatric Surgery·Susan TsaiD H Teitelbaum
Mar 1, 1997·JPEN. Journal of Parenteral and Enteral Nutrition·D H TeitelbaumM A Schork

Citations

Mar 1, 1978·Acta Physiologica Scandinavica·I HolmM Hellgren
Apr 1, 1976·The Journal of Surgical Research·A M EbeidJ E Fischer
Aug 1, 1970·The American Journal of Physiology·S ErlingerM Dumont
Jan 1, 1966·Acta Physiologica Scandinavica·E Jorpes, V Mutt
Jun 6, 1931·The Journal of Physiology·U S V Euler, J H Gaddum

Related Concepts

CCK-33
Diastolic Blood Pressure
Potassium
Vasoactive Intestinal Peptide
Enteric Hormones
Sodium
Amylases
Hydrocholeretics
Hypothalamic Substance P
Hydrogen-Ion Concentration

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.