Effect of subthalamic deep brain stimulation on turning kinematics and related saccadic eye movements in Parkinson disease.

Experimental Neurology
Corey A Lohnes, G M Earhart

Abstract

Persons with Parkinson disease (PD) experience turning difficulty, often leading to freezing of gait and falls. Visual information plays a significant role in locomotion and turning, and while the effects of deep brain stimulation (DBS) on oculomotor function have been well documented, the effects of DBS on oculomotor function during turning and on turning itself have yet to be fully elucidated. To determine the effects of STN DBS on turning performance and related oculomotor performance in PD. Eleven subjects with PD and DBS of the subthalamic nucleus performed a seated voluntary saccade task and standing 180° turns in DBS OFF and DBS ON conditions. Oculomotor data were captured using an infrared eye tracking system while segment rotations were measured using 3-D motion capture. During the seated saccade task, DBS did not improve saccade amplitude or latency. DBS also did not improve gait velocity and stride length during forward walking. During turning, DBS improved turn performance (turn duration), reduced the number of saccades performed during the turns, and increased the amplitude and velocity of the saccade initiating the turn. DBS decreased the intersegmental latencies (eye-head, eye-foot, and head-trunk) but this effec...Continue Reading

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Citations

Apr 30, 2013·Current Neurology and Neuroscience Reports·Elke HeremansSarah Vercruysse
Apr 5, 2013·Journal of Neuroengineering and Rehabilitation·Maria H NilssonPer-Anders Fransson
Feb 26, 2013·Brain : a Journal of Neurology·Neil K ArchibaldDavid J Burn
Oct 18, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Gammon M Earhart
Mar 13, 2015·Experimental Brain Research·Dimitri AnastasopoulosAdolfo M Bronstein
May 21, 2016·Frontiers in Behavioral Neuroscience·Petra FischerPeter König
Jun 23, 2018·Journal of Neurosurgery·Ariel TankusJeffrey M Hausdorff
Aug 9, 2018·Journal of Movement Disorders·Anshul SrivastavaCodrin Lungu
Dec 8, 2015·Current Opinion in Neurology·James J FitzGerald, Chrystalina A Antoniades
Jul 10, 2020·The European Journal of Neuroscience·Maja Klarendic, Diego Kaski
Dec 5, 2013·Current Opinion in Neurology·Anna Willard, Christian J Lueck

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