Effect of subthalamic nucleus deep brain stimulation on driving in Parkinson disease

Neurology
Carsten BuhmannWolfgang H Zangemeister

Abstract

To examine the influence of subthalamic nucleus (STN) deep brain stimulation (DBS) on driving in patients with Parkinson disease (PD). Using a driving simulator setup proven to reflect on-road driving, 2 main analyses were performed: 1) comparison of driving performance among 23 patients with deep brain surgery (DBS patients), 21 patients without surgery (no-DBS patients), and 21 controls; and 2) analysis of the effect of stimulation vs levodopa on driving performance. To this end, 3 tests were run in the medicated DBS patient cohort, with 3 different conditions: "stimulation on" (STIM) (equated to daily treatment), "stimulation off" (OFF), and "stimulation off/levodopa" (LD) (dosage aimed at maintaining motor status). Differences in driving times and errors among conditions were analyzed. Age and cognitive deficits influenced driving performance negatively. The no-DBS patient group performed worse in driving time and driving errors than controls. DBS patients drove slower than controls and no-DBS patients. Driving safety was comparable to controls but higher than in no-DBS patients. Within the DBS patient group, driving was more accurate with STIM than with LD, although motor effects did not differ. Driving with STIM, but not ...Continue Reading

Citations

Jun 17, 2014·Expert Review of Medical Devices·Carsten Buhmann, Christian Gerloff
May 27, 2014·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·Barbara Godden
Aug 8, 2014·Cell Biochemistry and Biophysics·Yingqun Tao, Guobiao Liang
May 21, 2016·Frontiers in Behavioral Neuroscience·Petra FischerPeter König
Oct 23, 2020·Geriatrics·Michael FalkensteinUte Brüne-Cohrs

Related Concepts

Automobile Driving
Levopa
Parkinson Disease
Structure of Subthalamic Nucleus
Electrical Stimulation of the Brain
Classification
Levodopa
Simulators
Operation on Brain
Impaired Cognition

Related Feeds

Brain-Computer Interface

A brain-computer interface, also known as a brain-machine interface, is a bi-directional communication pathway between an external device and a wired brain. Here is the latest research on this topic.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.