PMID: 3755683Jan 1, 1986Paper

Effect of sucralfate on the bioavailability of cimetidine

European Journal of Clinical Pharmacology
H AlbinM Amouretti

Abstract

Twelve, healthy fasting, subjects received 200 mg cimetidine orally either with water or 1 g sucralfate in a randomized, single dose, two-way crossover study. Blood samples were taken for 12 h and urine was collected for 24 h. Cimetidine in plasma and urine was analysed by HPLC. There was no significant difference between the two treatments in peak plasma concentration, time to peak plasma concentration, area under the plasma concentration-time curve and urinary excretion. The results indicate that sucralfate did not reduce the bioavailability of cimetidine.

References

Jul 1, 1977·Clinical Pharmacokinetics·A Hurwitz
Jan 1, 1985·British Journal of Clinical Pharmacology·F KamaliG D Bell
Jun 1, 1984·Revista de medicina de la Universidad de Navarra·M Muñoz NavasF Conchillo
Jan 1, 1984·European Journal of Clinical Pharmacology·H AlbinA Bedjaoui
Jan 1, 1981·European Journal of Clinical Pharmacology·R GuglerA Somogyi

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Citations

Oct 3, 1991·The New England Journal of Medicine·D M McCarthy
Apr 18, 2016·European Journal of Drug Metabolism and Pharmacokinetics·Suresh P SulochanaNuggehally R Srinivas
Mar 3, 2010·Journal of Feline Medicine and Surgery·Lauren Trepanier

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