Effect of sucralfate on the viscosity of gastric mucus and the permeability to hydrogen ion

Digestion
B L SlomianyA Slomiany

Abstract

The effect of sucralfate on the viscosity of pig gastric mucus and on its ability to retard the diffusion of hydrogen ion was investigated. Using a cone/plate viscometer at shear rates between 1.15 and 230 s-1, it was found that preincubation of mucus with increasing concentrations of sucralfate led to a gradual enhancement of the mucus viscosity. This enhancement in viscosity was proportional to the sucralfate concentration up to 1.0 X 10(-4) M and increased about 18% for each 10-fold increment in its concentration. The permeability measurements, conducted in a specially designed two compartment chamber, revealed that addition of sucralfate to gastric mucus had a profound beneficiary effect on its ability to retard the diffusion of hydrogen ion. In the presence of 1.0 X 10(-6) M sucralfate the permeability of mucus to hydrogen ion decreased by 35%, while the 1.0 X 10(-3) M sucralfate reduced the mucus permeability by 68%. The results show that sucralfate increases the viscosity of gastric mucus and improves its ability to impede the hydrogen ion penetration.

Citations

Jan 1, 1991·General Pharmacology·B L SlomianyA Slomiany
Jul 1, 1992·General Pharmacology·B L SlomianyA Slomiany
Mar 1, 1991·Alcoholism, Clinical and Experimental Research·B L SlomianyA Slomiany
Sep 1, 1989·Scandinavian Journal of Gastroenterology·S J KonturekJ Stachura
Jan 1, 1990·Scandinavian Journal of Gastroenterology. Supplement·M Tryba
Jan 1, 1992·Scandinavian Journal of Gastroenterology. Supplement·W D Rees
Jul 1, 1988·Baillière's Clinical Gastroenterology·I N Marks
Aug 8, 1991·The American Journal of Medicine·S J KonturekJ Pytko-Polonczyk
Aug 8, 1991·The American Journal of Medicine·W D Rees
Oct 1, 1987·Biochemical Pharmacology·B L SlomianyA Slomiany
Aug 8, 1991·The American Journal of Medicine·A MallR Hickman

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