Effect of sulfamethazine on sexual precocity and neuropeptide Y neurons within the tuberoinfundibular region of the chick brain

Brain Research Bulletin
K M Walsh, W J Kuenzel

Abstract

Neuropeptide Y (NPY) has been implicated in the sexual maturation process in chicks and other species. This study attempted to identify specific neural sites where NPY could influence gonadotrophin-releasing hormone (GnRH) neurons during maturation as evidenced by immunocytological changes. To do this sulfamethazine (SMZ), an antibiotic known to advance sexual maturation in male chicks, was used to elicit early testes development. One week posthatch, 20 chicks were fed either a control ration or one with 0.2% SMZ for 2 weeks or 5 weeks. At 3 and 6 weeks of age, birds were perfused through the heart, brains removed, and prepared for immunocytochemical assay for either NPY or GnRH. Results showed that chicks given SMZ had significantly greater testes weight compared to controls at both ages (p < or = 0.05) while body weight did not differ significantly between these groups at either age. The results of cell quantification showed no difference in the number of GnRH neurons between the SMZ chicks and controls in either the bed nucleus of the pallial commissure or the anterior lateral thalamic nucleus (LA) at 3 or 6 weeks of age. There was a significantly greater number of GnRH neurons found within the LA of 6-week compared to 3-wee...Continue Reading

References

Dec 22, 1991·The Journal of Comparative Neurology·O Güntürkün, H J Karten
Jan 1, 1988·Pharmacology & Therapeutics·E K Potter
Mar 1, 1987·The Journal of Comparative Neurology·F D SabatinoJ K McDonald
Aug 1, 1985·Neuroscience·B M ChronwallT L O'Donohue
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Sep 10, 1984·Life Sciences·S P Kalra, W R Crowley
Apr 10, 1982·The Journal of Comparative Neurology·W J Kuenzel, A van Tienhoven
Oct 1, 1994·Developmental Biology·R B Norgren, C Gao
Dec 1, 1993·Neuroendocrinology·K A Sullivan, A J Silverman

❮ Previous
Next ❯

Citations

Jun 26, 2013·Cell and Tissue Research·Singh DevrajVinod Kumar
May 5, 2004·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·W J KuenzelJ A Proudman
Jun 18, 2002·Journal of Neurochemistry·Sara K S HolmbergDan Larhammar
Jun 16, 2009·General and Comparative Endocrinology·Hongyan LiWayne J Kuenzel
Dec 9, 2014·General and Comparative Endocrinology·Seong W Kang, Wayne J Kuenzel
Sep 24, 1999·The Journal of Comparative Neurology·A CastroR Anadón
Mar 13, 2021·Acta histochemica·Boonyarit KamkrathokYupaporn Chaiseha

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.