Effect of sulfated glycosaminoglycan digestion on the transverse permeability of medial collateral ligament.

Journal of Biomechanics
Heath B HenningerJeffrey A Weiss

Abstract

Dermatan and chondroitin sulfate glycosaminoglycans (GAGs) comprise over 90% of the GAG content in ligament. Studies of their mechanical contribution to soft tissues have reported conflicting results. Measuring the transient compressive response and biphasic material parameters of the tissue may elucidate the contributions of GAGs to the viscoelastic response to deformation. The hypotheses of the current study were that digestion of sulfated GAGs would decrease compressive stress and aggregate modulus while increasing the permeability of porcine medial collateral ligament (MCL). Confined compression stress relaxation experiments were carried out on porcine MCL and tissue treated with chondroitinase ABC (ChABC). Results were fit to a biphasic constitutive model to derive permeability and aggregate modulus. Bovine articular cartilage was used as a benchmark tissue to verify that the apparatus provided reliable results. GAG digestion removed up to 88% of sulfated GAGs from the ligament. Removal of sulfated GAGs increased the permeability of porcine MCL nearly 6-fold versus control tissues. Peak stress decreased significantly. Bovine articular cartilage exhibited the typical reduction of GAG content and resultant decreases in stres...Continue Reading

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Citations

Apr 10, 2012·Journal of Biomechanical Engineering·Vincent P WillardKyriacos A Athanasiou
Apr 10, 2012·Journal of Biomechanical Engineering·LeAnn M DourteLouis J Soslowsky
Sep 10, 2011·Journal of Applied Physiology·Johannah Sanchez-AdamsKyriacos A Athanasiou
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Nov 22, 2011·Journal of the Mechanical Behavior of Biomedical Materials·Nathan T JacobsDawn M Elliott
Feb 11, 2015·Journal of Biomechanics·Markus BölMichael Ernst
Nov 4, 2016·Annals of Biomedical Engineering·Eric A KramerVirginia L Ferguson
Sep 4, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jared L Zitnay, Jeffrey A Weiss
Jan 23, 2015·Nature Communications·Admir MasicPeter Fratzl
Aug 11, 2018·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Stephen J PearsonPeter Malliaras

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