PMID: 20622461Jul 14, 2010Paper

Effect of sulfated modification on the molecular characteristics and biological activities of polysaccharides from Hypsizigus marmoreus

Bioscience, Biotechnology, and Biochemistry
Honghui BaoSangguan You

Abstract

The effect of sulfated modification on polysaccharides from Hypsizigus marmoreus was examined by determining their molecular structures and bioactivities. The sulfation, which was implemented by using an orthogonal array design, produced polysaccharides with varying degrees of substitution (DS) ranging from 0.11 to 1.06. The sulfated polysaccharides exhibited a lower average molecular weight (M(w)) and considerably higher radius of gyration (R(g)) than those of native polysaccharide, suggesting that the conformation of the sulfated polysaccharides had been changed towards a more extended type. The inhibitory activity toward cancer cell growth was enhanced by treating with the sulfated polysaccharides by up to 34%, as compared to the native polysaccharide. In addition, treating with the sulfated polysaccharides increased the nitric oxide (NO) and cytokine (IL-1beta and TNF-alpha) release to levels comparable to those detected in the positive control, lipopolysaccharide (LPS), suggesting that the sulfated polysaccharides might have strong immunomodulatory activity.

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Citations

Mar 21, 2013·International Journal of Biological Macromolecules·F T G S CardozoC M O Simões
Jun 27, 2015·International Journal of Biological Macromolecules·Zhi-Jun WangMing-Yong Xie
Sep 5, 2012·Carbohydrate Polymers·Aizhen ZongFengshan Wang
Dec 29, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hong Hui BaoSang Guan You
Nov 14, 2013·Experimental and Therapeutic Medicine·Chen-Feng JiDE-You Meng
Sep 27, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fei ChenYoulong Cao
May 16, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fangchen SuYue Geng

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