Effect of sulphated polysaccharides on the alpha 1-antitrypsin inhibition of amidolysis catalysed by coagulation cascade proteinases

British Journal of Pharmacology
W F Long, F B Williamson

Abstract

1 The ability of several sulphated polysaccharide anticoagulants to prevent alpha 1-antitrypsin inhibition of thrombin paralleled their ability to potentiate antithrombin III inhibition of thrombin. None of the compounds examined altered the ability of alpha 1-antitrypsin to inhibit activated coagulation factor X (Xa). 2 These results are consistent with the possibility that a direct polysaccharide-proteinase interaction may be involved in the sulphated polysaccharide-modulated inhibition of thrombin by antithrombin III.

References

Jan 1, 1979·Thrombosis Research·G KindnessJ Boyd
Jun 1, 1976·Thrombosis Research·A N TeienM Höök
Jun 13, 1979·Biochemical and Biophysical Research Communications·G KindnessW F Long
Dec 14, 1979·Biochemical and Biophysical Research Communications·I Danishefsky, R Pixley
May 1, 1978·British Medical Bulletin·T W BarrowcliffeD Thomas
Jan 1, 1979·Thrombosis Research·G KindnessF B Williamson
Aug 1, 1980·British Journal of Pharmacology·G KindnessF B Williamson
Oct 1, 1980·Biochemical Society Transactions·G KindnessW F Long
Jan 1, 1981·British Journal of Pharmacology·G KindnessF B Williamson
Apr 1, 1980·British Journal of Pharmacology·G KindnessF B Williamson

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Citations

Jul 1, 1983·Medical Hypotheses·W F Long, F B Williamson
May 31, 1983·Biochemical and Biophysical Research Communications·W F Long, F B Williamson
Nov 30, 1983·Biochemical and Biophysical Research Communications·W F Long, F B Williamson

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