Effect of sumac extract on serum oxidative status, RANKL/OPG system and alveolar bone loss in experimental periodontitis in rats

Journal of Applied Oral Science : Revista FOB
M SağlamEkrem Köksal

Abstract

Sumac (Rhus coriaria L.) is widely used spice which has several properties such as antioxidant, anti-inflammatory and antimicrobial. The purpose of this animal study was to evaluate the effects of sumac extract on levels of receptor activator of nuclear factor-kappa B ligand (RANKL), osteoprotegerin (OPG) expression, serum oxidative status, and alveolar bone loss in experimental periodontitis. Twenty-four Wistar rats were separated into three groups: non-ligated (NL, n=8), ligature only (LO, n=8), and ligature and treated with sumac extract (S, n=8) (20 mg/kg per day for 11 days). A 4/0 silk suture was placed around the mandibular right first molars subgingivally; after 11 days, the rats were sacrificed, and alveolar bone loss was histometrically measured. The detection of RANKL and OPG were immunohistochemically performed. Levels of serum total antioxidant status (TAS)/total oxidant status (TOS), and oxidative stress index (OSI) were also analyzed. Alveolar bone loss was significantly greater in the LO group compared to the S and NL groups (p<0.05). The number of inflammatory cell infiltrate (ICI) and osteoclasts in the LO group was significantly higher than that of the NL and S groups (p<0.05). The number of osteoblasts in th...Continue Reading

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Citations

Jan 28, 2016·Journal of Applied Oral Science : Revista FOB·Y I JianruZhihe Zhao
Apr 14, 2017·Journal of Applied Oral Science : Revista FOB·Bianca Fernanda Espósito SantosLeandro Araújo Fernandes
Nov 29, 2017·Frontiers in Physiology·Yue WangXiaohui Rausch-Fan
Jun 2, 2018·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Sadiye GunpinarGizem Soyler
Apr 5, 2019·Drug and Chemical Toxicology·Taygun TimocinHasan Basri Ila
Mar 7, 2020·Chemistry & Biodiversity·Zaha ElagbarHala Ihlal Al-Jaber
Feb 6, 2020·Experimental and Therapeutic Medicine·Masahiro Ohtani, Tsubasa Nishimura
Aug 12, 2016·Molecular Medicine Reports·Hua QianZhuan Bian
Jan 13, 2021·Antioxidants·Halima AlsamriRabah Iratni

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Methods Mentioned

BETA
dissection
light microscopy
Assay

Software Mentioned

SPSS

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