Effect of Superoxide Anion Scavenger on Rat Hearts with Chronic Intermittent Hypoxia

Journal of Applied Physiology
Pei-ying PaiShin-Da Lee

Abstract

Only very limited information regarding the protective effects of superoxide anion scavenger on chronic intermittent hypoxia-induced cardiac apoptosis is available. The purpose of this study is to evaluate the effects of superoxide anion scavenger on cardiac apoptotic and pro-survival pathways in rats with sleep apnea. Forty-two SD rats were divided into three groups, rats with normoxic exposure (CONTROL,21% O2,1 month), rats with chronic intermittent hypoxia exposure (HYPOXIA,3-7%O2 versus 21%O2 per 40 seconds cycle, 8 hrs per day, 1 month), and rats with pre-treatment of superoxide anion scavenger and chronic intermittent hypoxia exposure (HYPOXIA- O2- SCAVENGER, MnTMPyP Pentachloride, 1mg/kg, i.p. per day; 3-7%O2 versus 21%O2 per 40seconds cycle, 8 hrs per day, 1 month) at 5-6 months of age. After 1 month, the protein levels and apoptotic cells of excised hearts from three groups were measured by Western blotting and TUNEL assay. Superoxide anion scavenger decreased HYPOXIA-induced myocardial architecture abnormalities, left ventricular hypertrophy and TUNEL-positive apoptosis. Superoxide anion scavenger decreased HYPOXIA-induced Fas ligand, Fas death receptors, Fas-associated death domain (FADD), activated caspase-8, and ac...Continue Reading

References

Jun 20, 1998·Circulation Research·A Haunstetter, S Izumo
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·J NarulaS Kharbanda
Sep 16, 2000·Biochemical Society Symposium·G C Brown, V Borutaite
Mar 21, 2001·Methods and Findings in Experimental and Clinical Pharmacology·H Y SunJ M Zhi
Nov 21, 2001·Current Opinion in Pharmacology·N H BishopricK A Webster
Aug 15, 2002·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Andrea M Vincent, Eva L Feldman
Apr 13, 2004·Oncogene·Sean P CreganRuth S Slack
Apr 28, 2004·Vitamins and Hormones·Bharat B AggarwalYasunari Takada
Jun 25, 2005·American Journal of Respiratory and Critical Care Medicine·Ling ChenSteven M Scharf
Jul 11, 2006·American Journal of Physiology. Endocrinology and Metabolism·Shin-Da LeeChih-Yang Huang
Dec 23, 2006·Experimental Physiology·Li-Mien ChenShin-Da Lee
Jan 19, 2008·Journal of Applied Physiology·Shin-Da LeeChih-Yang Huang
Oct 15, 2013·Journal of Physiology and Biochemistry·Qian HanJudith C W Mak
May 16, 2014·International Journal of Cardiology·Mei-Chih LaiShin-Da Lee

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