Abstract
Only very limited information regarding the protective effects of superoxide anion scavenger on chronic intermittent hypoxia-induced cardiac apoptosis is available. The purpose of this study is to evaluate the effects of superoxide anion scavenger on cardiac apoptotic and pro-survival pathways in rats with sleep apnea. Forty-two SD rats were divided into three groups, rats with normoxic exposure (CONTROL,21% O2,1 month), rats with chronic intermittent hypoxia exposure (HYPOXIA,3-7%O2 versus 21%O2 per 40 seconds cycle, 8 hrs per day, 1 month), and rats with pre-treatment of superoxide anion scavenger and chronic intermittent hypoxia exposure (HYPOXIA- O2- SCAVENGER, MnTMPyP Pentachloride, 1mg/kg, i.p. per day; 3-7%O2 versus 21%O2 per 40seconds cycle, 8 hrs per day, 1 month) at 5-6 months of age. After 1 month, the protein levels and apoptotic cells of excised hearts from three groups were measured by Western blotting and TUNEL assay. Superoxide anion scavenger decreased HYPOXIA-induced myocardial architecture abnormalities, left ventricular hypertrophy and TUNEL-positive apoptosis. Superoxide anion scavenger decreased HYPOXIA-induced Fas ligand, Fas death receptors, Fas-associated death domain (FADD), activated caspase-8, and ac...Continue Reading
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