Abstract
In bronchial asthma, inflammatory cells infiltrating the airway mucosa release oxygen radicals that cause tissue damage and amplify the airway inflammation. Antioxidant enzymes may have a protective effect on the airways. The purpose of this study was to determine whether treatment of a rabbit model of chronic allergic asthma with the antioxidant enzyme superoxide dismutase conjugated to polyethylene glycol will protect the airways from oxygen radical injury, decrease airway inflammation, and attenuate the asthmatic response. New Zealand white rabbits were sensitized to ragweed. Baseline histamine PC30, ragweed PD30, and early and late phase asthmatic response to ragweed bronchial challenge were measured. The rabbits were then randomized into two groups that received every 48 hours an intravenous dose of either superoxide dismutase-polyethylene glycol 10,000 U/kg or inactivated superoxide dismutase-polyethylene glycol as control, followed by a 1-hour exposure to aerosolized ragweed extract. After 4 weeks the rabbits had a second bronchial challenge, were sacrificed, and lung histology was studied. On the posttreatment challenge, the superoxide dismutase-polyethylene glycol group had a rise in ragweed PD30, while the control gro...Continue Reading
References
Jul 1, 1976·Journal of Applied Physiology·J H Fleisch, P J Calkins
Oct 1, 1992·The American Review of Respiratory Disease·N N JarjourW J Calhoun
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J D CrapoL Y Chang
May 1, 1992·The Journal of Allergy and Clinical Immunology·D H BroideS I Wasserman
Nov 1, 1992·The American Review of Respiratory Disease·I VachierP Godard
Aug 1, 1992·The American Review of Respiratory Disease·R H GundelL G Letts
Jan 1, 1991·International Archives of Allergy and Applied Immunology·M KatoT Kuroume
Nov 1, 1991·Chest·H KanazawaT Takeda
Jan 1, 1990·Free Radical Biology & Medicine·C J Doelman, A Bast
Feb 1, 1992·The American Review of Respiratory Disease·Y SuzukiT A Raffin
Jun 1, 1991·Proceedings of the Society for Experimental Biology and Medicine·R A DiSilvestroC Collignon
Sep 1, 1990·The Journal of Allergy and Clinical Immunology·W J Calhoun, R K Bush
Mar 1, 1990·Journal of Applied Physiology·J M JacobsonG H Gurtner
Jul 1, 1990·The American Journal of the Medical Sciences·R M JacksonA L Brannen
May 15, 1989·Analytical Biochemistry·D R Spitz, L W Oberley
Mar 1, 1989·The American Review of Respiratory Disease·R BeasleyS T Holgate
Nov 1, 1984·The Journal of Pediatrics·W RosenfeldA Friedman
Dec 1, 1993·Journal of Pharmacological and Toxicological Methods·E M MinshallC P Page
Jan 1, 1993·International Archives of Allergy and Immunology·M KurosawaM Nakano
Jun 1, 1993·Inflammation·B Z JosephL Borish
Jan 1, 1993·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·M Inagaki
Jun 1, 1993·The American Review of Respiratory Disease·L J SmithJ Anderson
Citations
Jun 25, 2013·Pharmaceutical Research·Julie CarillonRichard Brion
May 16, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·J M MatésM Blanca
Mar 14, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·V R Muzykantov
Apr 9, 2001·Antioxidants & Redox Signaling·V R Muzykantov
Jan 9, 2008·Antioxidants & Redox Signaling·Tomoaki HoshinoHisamichi Aizawa
Sep 23, 2003·Critical Care Medicine·Russell P BowlerBrian J Day
Jun 11, 2003·American Journal of Respiratory and Critical Care Medicine·Vuokko L Kinnula, James D Crapo
Dec 10, 2002·American Journal of Respiratory and Critical Care Medicine·Russell P Bowler, James D Crapo
Jan 18, 2006·Treatments in Respiratory Medicine·Melpo Christofidou-Solomidou, Vladimir R Muzykantov
Feb 13, 2014·Mucosal Immunology·N VoraphaniS E Wenzel
Aug 19, 2004·The Journal of Allergy and Clinical Immunology·You Sook ChoHee-Bom Moon
Jan 10, 2002·Pulmonary Pharmacology & Therapeutics·P A Henricks, F P Nijkamp
Mar 19, 2015·American Journal of Rhinology & Allergy·Lauren A LawrenceRodney J Schlosser
Dec 21, 2004·Journal of Applied Physiology·Natalia Skorohod, Donovan B Yeates
May 26, 2016·The Cochrane Database of Systematic Reviews·Maria José Martinez-ZapataCarlos Zaror
Nov 16, 2012·The Cochrane Database of Systematic Reviews·Susan O'MearaJo C Dumville
Apr 24, 2004·The Cochrane Database of Systematic Reviews·H VermeulenD Legemate
Sep 18, 2002·Journal of Applied Physiology·S M Smiley-JewellC G Plopper
Jan 23, 2004·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·K KatsoulisD Patakas
Sep 23, 2009·American Journal of Rhinology & Allergy·Ryan M MulliganRodney J Schlosser
Sep 22, 2006·Medicina clínica·María Teresa Ramírez-PrietoJosé Villamor
Apr 27, 2007·Nitric Oxide : Biology and Chemistry·Claus G KrennJosephine Hjoberg