Effect of supplemental chromium on whole-body kinetics of glucose, lactate, and propionate in rams fed a high grain diet

Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
H SanoD R Trout

Abstract

The isotope dilution technique of [6-3H]glucose, [U-14C]lactate and [l-14C]propionate was used to evaluate the effect of dietary chromium (Cr) supplementation on whole-body kinetics of glucose, lactate, and propionate in rams. Rams were fed a high grain diet at 2% of body weight with or without 0.5 ppm of supplemental Cr from chelated Cr for the initial 14 days, and then intake was increased to 2.5% at body weight for the last 9 days. Weight gain was enhanced (P < 0.01) with Cr supplementation. Plasma concentrations of glucose, lactate, and propionate were not influenced by Cr supplementation. Turnover rates of glucose and lactate, and their interconversion were also not influenced. Propionate turnover rate tended to increase (P = 0.11) and the conversion of propionate to glucose increased (P < 0.05) with Cr supplementation, leading the increased proportional contribution of propionate to glucose turnover rate (P < 0.05). Chromium supplementation may influence the contribution of each glucogenic substrate for glucose production in rams fed a high grain diet.

References

Jan 1, 1975·The British Journal of Nutrition·E Evans, J G Buchanan-Smith
Aug 1, 1986·Canadian Journal of Physiology and Pharmacology·R P Brockman, B Laarveld
Jan 16, 2007·Journal of Animal Physiology and Animal Nutrition·H SanoM Al-Mamun
May 6, 2016·Annual Review of Nutrition·Chrysi Koliaki, Michael Roden

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