Effect of Supplemental Oxygen on Blood Pressure in Obstructive Sleep Apnea (SOX). A Randomized Continuous Positive Airway Pressure Withdrawal Trial.

American Journal of Respiratory and Critical Care Medicine
Chris D TurnbullJohn R Stradling

Abstract

Obstructive sleep apnea (OSA) is associated with systemic hypertension. Either overnight intermittent hypoxia, or the recurrent arousals that occur in OSA, could cause the daytime increases in blood pressure (BP). To establish the role of intermittent hypoxia in the increased morning BP in patients with OSA. Randomized, double-blinded, crossover trial assessing the effects of overnight supplemental oxygen versus air (sham) on morning BP, after continuous positive airway pressure (CPAP) withdrawal in patients with moderate to severe OSA. The primary outcome was the change in home morning BP after CPAP withdrawal for 14 nights, oxygen versus air. Secondary outcomes included oxygen desaturation index (ODI), apnea-hypopnea index (AHI), subjective sleepiness (Epworth Sleepiness Scale score), and objective sleepiness (Oxford Sleep Resistance Test). Supplemental oxygen virtually abolished the BP rise after CPAP withdrawal and, compared with air, significantly reduced the rise in mean systolic BP (-6.6 mm Hg; 95% confidence interval [CI], -11.3 to -1.9; P = 0.008), mean diastolic BP (-4.6 mm Hg; 95% CI, -7.8 to -1.5; P = 0.006), and median ODI (-23.8/h; interquartile range, -31.0 to -16.3; P < 0.001) after CPAP withdrawal. There was no...Continue Reading

References

Mar 26, 1994·BMJ : British Medical Journal·R J DaviesJ R Stradling
Jan 1, 1997·The Journal of Clinical Investigation·D BrooksE A Phillipson
May 11, 2000·The New England Journal of Medicine·P E PeppardJ Skatrud
Mar 1, 1965·Acta Physiologica Scandinavica·P LINDGREN, J MANNING
May 6, 2008·Lancet·Carlene M M LawesUNKNOWN International Society of Hypertension
Nov 17, 2010·Nature Reviews. Cardiology·Malcolm Kohler, John R Stradling
Aug 13, 2011·American Journal of Respiratory and Critical Care Medicine·Malcolm KohlerJohn R Stradling
Mar 16, 2013·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Vanita MehtaFrances Chung
Jun 12, 2014·The New England Journal of Medicine·Daniel J GottliebSusan Redline
May 24, 2015·Circulation·Dion StubUNKNOWN AVOID Investigators
Jun 16, 2015·Respirology : Official Journal of the Asian Pacific Society of Respirology·Esther I SchwarzMalcolm Kohler
Dec 2, 2015·JAMA : the Journal of the American Medical Association·Daniel J BrattonMalcolm Kohler

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Citations

Aug 1, 2018·American Journal of Respiratory and Critical Care Medicine·Daniel J Gottlieb
Aug 23, 2019·Current Opinion in Pulmonary Medicine·Esther I Schwarz
Sep 14, 2019·American Journal of Respiratory and Critical Care Medicine·Chris D TurnbullNayia Petousi
Apr 15, 2020·JAMA : the Journal of the American Medical Association·Daniel J Gottlieb, Naresh M Punjabi
Apr 16, 2020·American Journal of Respiratory and Critical Care Medicine·Eileen B LearyReena Mehra
Jun 20, 2020·Journal of Applied Physiology·Caroline B FerreiraSergio L Cravo
Jan 1, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Lihong ChenXingwu Ran
Aug 19, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Omar Mesarwi, Atul Malhotra
Mar 23, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Waled M AlshhraniFernanda R Almeida
Feb 22, 2021·Chest·Salam ZeineddineSusmita Chowdhuri
Apr 27, 2021·Cranio : the Journal of Craniomandibular Practice·Waled M AlshhraniFernanda R Almeida
May 16, 2021·Pulmonary Therapy·Charlotte A WigstonChris D Turnbull
Jun 3, 2021·International Journal of Molecular Sciences·Jakub MocholAdrian Doroszko
Aug 10, 2021·Chest·Chris D Turnbull, Luu V Pham

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Clinical Trials Mentioned

ISRCTN17987510

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SPSS
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