Effect of Supplementation of a Whey Peptide Rich in Tryptophan-Tyrosine-Related Peptides on Cognitive Performance in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study

Nutrients
Masahiro KitaYasuhisa Ano

Abstract

Background: Previous epidemiological and clinical studies have shown that dairy products have beneficial effects on cognitive decline and dementia. Enzymatic digestion of whey protein produces a whey peptide rich in tryptophan-tyrosine-related peptides which improve cognitive performance in mice. We evaluated the effects of whey peptides on cognitive functions in healthy adults in a randomized, double-blind, placebo-controlled design. Methods: 101 healthy adults (45 to 64 years), with a self-awareness of cognitive decline received either whey peptide or placebo supplements for 12 weeks. Changes in cognitive function were assessed using neuropsychological tests at 6 and 12 weeks after the start of supplementation. Results: Verbal fluency test (VFT) score changes tended to be higher in the whey peptide group compared with the placebo at 12 weeks. Subgroup analysis classified by the degree of subjective fatigue showed that changes in the VFT as well as the Stroop and subjective memory function tests between baseline and 6 weeks of intervention were significantly better in subjects with high-level fatigue from the whey peptide group as compared to the placebo group. Intake of whey peptide might improve cognitive function in healthy...Continue Reading

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Citations

Mar 30, 2019·Aging·Yasuhisa Ano, Hiroyuki Nakayama
Aug 28, 2020·Frontiers in Human Neuroscience·Blanka KlimovaAnna Cierniak-Emerych
Jan 14, 2020·Journal of Alzheimer's Disease : JAD·Yasuhisa AnoHiroyuki Nakayama
Apr 9, 2021·The American Journal of Clinical Nutrition·Leah H RubinSheri D Weiser
Jul 17, 2021·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Mandy RohegerMarcus Meinzer
Dec 7, 2019·Journal of Agricultural and Food Chemistry·Takafumi FukudaYasuhisa Ano
Sep 10, 2021·Frontiers in Nutrition·Yasuhisa AnoHiroyuki Nakayama

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