PMID: 9436868Jan 22, 1998Paper

Effect of supramaximal cerulein stimulation on mitochondrial energy metabolism in rat pancreas

Pancreas
W HalangkH Lippert

Abstract

Hyperstimulation with the cholecystokinin analogue cerulein induces mild edematous pancreatitis in rats. It is believed that an impaired energy metabolism diminishes the cellular defense capacity in the inflamed pancreatic tissue and, therefore, contributes to the injuries in acinar cells. In the present study, changes in the capacity of oxidative phosphorylation were quantified within the first 24 h after subcutaneous cerulein injections. Serum amylase level and pancreatic water content were maximally elevated 5 h after the first injection. The capacity of mitochondrial respiration was reduced in isolated acinar cells to 69 and 44% at 5 and 24 h, respectively, compared to that in saline controls. Simultaneously, glutamate dehydrogenase (GLDH) activity dropped to 70 and 46%. The respiration rates of acinar cells and of isolated mitochondria related to GLDH activities were not different from controls. This suggests that the major portion of the mitochondrial population within the acinar cell is inactivated in the course of cerulein treatment. After 24 h, the reduced population of functionally intact mitochondria restricted the rate of phosphorylating respiration in acinar cells (52%), which resulted in a diminution of cellular A...Continue Reading

Citations

Apr 12, 2001·Neuromuscular Disorders : NMD·M ToyonoH Sugie
Apr 14, 2007·Cell Death and Differentiation·D N CriddleO V Gerasimenko
May 31, 2013·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Sonata TrumbeckaiteAntanas Gulbinas
Sep 28, 2007·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·David N CriddleRobert Sutton
Oct 6, 2006·American Journal of Medical Genetics. Part a·François-Guillaume DebrayJacques L Michaud
Mar 13, 2014·Cell Calcium·Svetlana VoroninaAlexei Tepikin
Jul 15, 2015·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·József MaléthViktória Venglovecz
Jun 26, 2012·Molecular Genetics and Metabolism·Carlos E PradaT Andrew Burrow
May 11, 2012·Cell Calcium·Svetlana Voronina, Alexei Tepikin
Jan 28, 2010·Gastroenterology·Svetlana G VoroninaAlexei V Tepikin
Apr 10, 2012·Archives of Biochemistry and Biophysics·Aya SakaiMasaru Yoshida
Jul 31, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Mandira ChakrabortyAnthony R J Phillips

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