Effect of surface alkali-based treatment of titanium implants on ability to promote in vitro mineralization and in vivo bone formation

Acta Biomaterialia
Winston A CamargoHamdan S Alghamdi

Abstract

This study investigated whether a novel alkali-based surface modification enhances in vitro mineralization as well as in vivo bone formation around titanium (Ti) implants in a femoral condyle model of 36 male Wister rats. All implant surfaces were grit-blasted and then received either acid-etching treatment, alkali-based treatment, or were left untreated (controls). Histological and histomorphometrical analyses were performed on retrieved specimens after 4 and 8weeks of healing to assess peri-implant bone formation. Results of implants surface characterisation showed notable differences in the topography and composition of alkali-treated surfaces, reflecting the formation of submicron-structured alkali-titanate layer. In the in vitro test, alkali-treated Ti surfaces showed the ability to stimulate mineralization upon soaking in simulated body fluid (SBF). In vivo histomorphometrical analyses showed similar values for bone area (BA%) and bone-to-implant contact (BIC%) for all experimental groups after both 4- and 8-week implantation periods. In conclusion, the surface topography and composition of the grit-blasted Ti implants was significantly modified using alkali-based treatment. With respect to the present in vivo model, the ...Continue Reading

References

Nov 3, 2009·NDT Plus·Robert ZietseEwout J Hoorn

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Citations

May 26, 2020·Dental Materials Journal·Hanako UmeharaKazuhiro Tsuga
Dec 20, 2018·Journal of Materials Science. Materials in Medicine·Meng ZhangBin Tang
Jan 4, 2019·Biomedical Engineering Letters·Javad Tavakoli, Mohammad E Khosroshahi
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Zhen GengChangsheng Liu
Dec 12, 2020·Materials·Tatiana AvilesJosephine F Esquivel-Upshaw
May 1, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Fengxiong LuoXingdong Zhang
Aug 25, 2021·Dental Materials : Official Publication of the Academy of Dental Materials·Marcel F KunrathMaria M Campos
Jul 4, 2018·ACS Applied Materials & Interfaces·Noushin NasiriAntonio Tricoli

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