Effect of surface grafted polymers on the adsorption of different model proteins

Colloids and Surfaces. B, Biointerfaces
Malin Jönsson, H -O. Johansson

Abstract

Adsorption of a model protein to a surface with end-grafted polymers was studied by Monte Carlo simulations. In the model the effect on protein adsorption in the presence of end-grafted polymers was evaluated by calculating the change in free energy between an end-grafted surface and a surface without polymers. The change in free energy was calculated using statistical mechanical perturbation theory. Apart from ordinary athermal polymer-polymer and protein-polymer interactions we also study a broad selection of systems by varying the interaction between proteins and polymers and effective polymer-solvent interactions. The interactions between the molecules span an interval from -0.5 to +0.5 kT. Consequently, general features of protein adsorption to end-grafted surfaces is investigated by systematically changing properties like hydrophilicity/hydrophobicity of the polymer, protein and surface as well as grafting density, degree of polymerization and protein size. Increasing grafting density as well as degree of polymerization decreases the adsorption of protein except in systems with attractive polymer-protein interactions, where adsorption increases with increasing chain length and higher grafting density. At a critical polyme...Continue Reading

References

Apr 18, 1998·Biochimica Et Biophysica Acta·H LakhiariJ Jozefonvicz
Feb 15, 2001·Colloids and Surfaces. B, Biointerfaces·G Karlström, H -O. Johansson

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Citations

Mar 18, 2010·Journal of Biomaterials Science. Polymer Edition·Mohamed A ShakerHusam M Younes
Oct 9, 2012·The Journal of Chemical Physics·S A Egorov
Mar 2, 2016·Colloids and Surfaces. B, Biointerfaces·Yuanyuan HanWei Jiang
Jul 16, 2013·Journal of Biomedical Materials Research. Part a·Milica SpasojevicPaul de Vos
Apr 5, 2005·Biophysical Journal·Yevgeny Moskovitz, Simcha Srebnik
Nov 5, 2011·Macromolecular Bioscience·Motohiro TagayaToshiyuki Ikoma
Apr 14, 2020·Physical Chemistry Chemical Physics : PCCP·Tomasz Staszewski, Małgorzata Borówko
Sep 20, 2010·Science and Technology of Advanced Materials·Motohiro TagayaJunzo Tanaka
Oct 9, 2012·The Journal of Physical Chemistry. B·M BorówkoT Staszewski
Aug 28, 2021·International Journal of Molecular Sciences·Małgorzata Borówko, Tomasz Staszewski
Oct 4, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Hans-Olof Johansson, James M Van Alstine
Jan 10, 2006·Biomacromolecules·Ruben Y KannanAlexander M Seifalian

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