PMID: 9532272Apr 9, 1998Paper

Effect of surface modifications of intraocular lenses on the adherence of Staphylococcus epidermidis

Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology
H SchmidtR Guthoff

Abstract

The development of polymers with different surface properties and surface modifications of intraocular lenses (IOL) should reduce foreign body reactions after implantation by reducing the surface hydrophobicity of the lenses. It was examined how far such surface variations influenced the adhesiveness of bacteria. The most common organism isolated from cases of postoperative endophthalmitis is Staphylococcus epidermidis. For this reason, three strains of this species, the type strain ATCC 14990 and two clinical isolates (8687, 6579 I), with different hydrophobic surfaces, were studied. IOL made of PMMA, silicone, and a copolymer as well as PMMA lenses with modified surfaces (unpolished, polished, silanized, and heparinized) were used. Bacteria were radiolabelled with 3H-thymidine and the adherent bacteria were calculated per mm2 of lens surface. The three strains adhered better to the unpolished surface of silicone than to PMMA. Treatment of PMMA surface by polishing diminished the differences between the strains. An influence of hydrophobic interactions on the adherence of S. epidermidis ATCC 14990 was demonstrated. The adherence of this hydrophobic type strain was clearly reduced by heparinization of the PMMA surface. In contr...Continue Reading

References

Mar 1, 1992·Klinische Monatsblätter für Augenheilkunde·V RummeltG O Naumann
Jun 1, 1989·The British Journal of Ophthalmology·P G GriffithsL McTaggart
Sep 1, 1983·Journal of General Microbiology·A H HogtJ Feijen
Jun 1, 1981·Proceedings of the Society for Experimental Biology and Medicine·B Sugarman, D Musher
May 1, 1993·Journal of Cataract and Refractive Surgery·K OkadaY Ishii

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Citations

May 25, 2004·Antimicrobial Agents and Chemotherapy·Faten GadMichael R Hamblin
Mar 20, 2004·Journal of Cataract and Refractive Surgery·Rita MencucciUgo Menchini
Feb 28, 2002·Drug Development and Industrial Pharmacy·Carole BurillonFrançois N R Renaud
Jan 10, 2002·Clinical & Experimental Ophthalmology·S LertsumitkulJ Chandra

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