Abstract
As United States Food and Drug Administration-approved implantable material, carbon fiber-reinforced polyetheretherketone (CFRPEEK) possesses an adjustable elastic modulus similar to cortical bone and is a prime candidate to replace surgical metallic implants. The bioinertness and inferior osteogenic properties of CFRPEEK, however, limit its clinical application as orthopedic/dental implants. In this study, CFRPEEK-nanohydroxyapatite ternary composites (PEEK/n-HA/CF) with variable surface roughness have been successfully fabricated. The effect of surface roughness on their in vitro cellular responses of osteoblast-like MG-63 cells (attachment, proliferation, apoptosis, and differentiation) and in vivo osseointegration is evaluated. The results show that the hydrophilicity and the amount of Ca ions on the surface are significantly improved as the surface roughness of composite increases. In cell culture tests, the results reveal that the cell proliferation rate and the extent of osteogenic differentiation of cells are a function of the size of surface roughness. The composite with moderate surface roughness significantly increases cell attachment/proliferation and promotes the production of alkaline phosphatase (ALP) activity an...Continue Reading
Citations
Jan 13, 2016·ACS Applied Materials & Interfaces·Xiang GaoShicheng Wei
Mar 18, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Nathan T EvansKen Gall
Aug 19, 2016·ACS Applied Materials & Interfaces·Gráinne M CunniffeFergal J O'Brien
Oct 1, 2016·ACS Applied Materials & Interfaces·Xiang GaoShicheng Wei
Jun 7, 2017·Biomedical Materials·Feng ShiJie Weng
Mar 30, 2017·Biomedical Materials·Young Jung NoHala Zreiqat
Sep 25, 2019·Bioengineering·Heonuk JeongKatsuko S Furukawa
Oct 25, 2017·The Journal of Oral Implantology·Tarek ElawadlyReham B Osman
Feb 14, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Fatih Erdem Baştan
Aug 7, 2017·Journal of Biomedical Materials Research. Part a·Lu HanXiong Lu
Jul 3, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ralph M JeukenPieter J Emans
Apr 19, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·S AjamiG W Blunn
Feb 8, 2019·Frontiers in Bioengineering and Biotechnology·Maryam Rahmati, Masoud Mozafari
May 6, 2020·International Journal of Nanomedicine·Steven D NewbyMadhu Dhar
Jan 20, 2021·Iranian Biomedical Journal·Yasaman ZamaniMarco N Helder
Jan 30, 2021·Frontiers in Bioengineering and Biotechnology·Xinming GuYanmin Zhou
Mar 26, 2021·ACS Applied Materials & Interfaces·Lan WangGui Wang
May 1, 2021·Journal of Clinical Medicine·Stefanie KligmanChenshuang Li
Jul 15, 2020·The Journal of Oral Implantology·Sara Pourshahidi, Marzieh Yousefain
Jul 31, 2021·Nanotechnology·Guoyong WangCijun Shuai
Nov 27, 2018·ACS Applied Materials & Interfaces·Chuchao ZhouZhenxing Wang
Jan 7, 2022·ACS Biomaterials Science & Engineering·Minyan LiuXinpei Li