Effect of surface roughness on osteogenesis in vitro and osseointegration in vivo of carbon fiber-reinforced polyetheretherketone-nanohydroxyapatite composite

International Journal of Nanomedicine
Yi DengShicheng Wei

Abstract

As United States Food and Drug Administration-approved implantable material, carbon fiber-reinforced polyetheretherketone (CFRPEEK) possesses an adjustable elastic modulus similar to cortical bone and is a prime candidate to replace surgical metallic implants. The bioinertness and inferior osteogenic properties of CFRPEEK, however, limit its clinical application as orthopedic/dental implants. In this study, CFRPEEK-nanohydroxyapatite ternary composites (PEEK/n-HA/CF) with variable surface roughness have been successfully fabricated. The effect of surface roughness on their in vitro cellular responses of osteoblast-like MG-63 cells (attachment, proliferation, apoptosis, and differentiation) and in vivo osseointegration is evaluated. The results show that the hydrophilicity and the amount of Ca ions on the surface are significantly improved as the surface roughness of composite increases. In cell culture tests, the results reveal that the cell proliferation rate and the extent of osteogenic differentiation of cells are a function of the size of surface roughness. The composite with moderate surface roughness significantly increases cell attachment/proliferation and promotes the production of alkaline phosphatase (ALP) activity an...Continue Reading

Citations

Mar 18, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Nathan T EvansKen Gall
Aug 19, 2016·ACS Applied Materials & Interfaces·Gráinne M CunniffeFergal J O'Brien
Mar 30, 2017·Biomedical Materials·Young Jung NoHala Zreiqat
Feb 14, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Fatih Erdem Baştan
Jul 3, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ralph M JeukenPieter J Emans
Apr 19, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·S AjamiG W Blunn
Feb 8, 2019·Frontiers in Bioengineering and Biotechnology·Maryam Rahmati, Masoud Mozafari
Jan 30, 2021·Frontiers in Bioengineering and Biotechnology·Xinming GuYanmin Zhou
May 1, 2021·Journal of Clinical Medicine·Stefanie KligmanChenshuang Li
Jul 15, 2020·The Journal of Oral Implantology·Sara Pourshahidi, Marzieh Yousefain
Nov 27, 2018·ACS Applied Materials & Interfaces·Chuchao ZhouZhenxing Wang
Jan 7, 2022·ACS Biomaterials Science & Engineering·Minyan LiuXinpei Li

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Methods Mentioned

BETA
infrared spectrometry
X-ray
profiler
flow cytometry
protein assay

Software Mentioned

Amira
CTAn
GSA Image Analyser
CTVol

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