Effect of Surfactant Concentrations on Physicochemical Properties and Functionality of Curcumin Nanoemulsions Under Conditions Relevant to Commercial Utilization

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Thanida ChuacharoenCristina M Sabliov

Abstract

Surfactants are used to stabilize nanoemulsions by protecting their physical stability and preventing deterioration of the entrapped bioactive during processing and storage. The effect of surfactant concentration on physical-chemical properties of nanoemulsions with entrapped curcumin, relevant to commercial applications, was addressed in this research. Furthermore, the functionality of nanoemulsified curcumin in terms of lipid oxidation inhibition was determined. Protection against varying pH and thermal treatments was more significant in the nanoemulsions at the elevated surfactant level, but at these high concentrations, the surface charges of the emulsions dramatically decreased under sodium salt addition, which may result in instability over time. Nanoemulsions showed the potential to inhibit malondialdehyde (MDA) formulation by protecting the entrapped curcumin and enhance its antioxidant activity when added to milk. The fortified milk with added curcumin systems had a yellow color compared to the control. The results of the study are critical in choosing the surfactant concentration needed to stabilize emulsified curcumin, and to protect the entrapped curcumin under specific conditions of use to support the utilization o...Continue Reading

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Citations

Sep 20, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nikita SharmaSurendra Nimesh
Apr 23, 2021·Journal of Bioscience and Bioengineering·Jannatul FardousHiroyuki Ijima
May 6, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Jannatul FardousHiroyuki Ijima
Aug 8, 2021·International Journal of Molecular Sciences·Jelena B ĐokovićSnežana D Savić
Oct 19, 2020·Current Pharmaceutical Design·Drashti Patel, Bappaditya Chatterjee

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Methods Mentioned

BETA
MDA
dynamic light scattering

Software Mentioned

SAS

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