Effect of surfactant mixing on partitioning of model hydrophobic drug, naproxen, between aqueous and micellar phases

The Journal of Physical Chemistry. B
Parvaiz Ahmad BhatAijaz Ahmad Dar

Abstract

Mixed surfactants may improve the performance of surfactant-enhanced solubilization of drugs and thus can serve as the tool for increased bioavalaibility, controlled drug release, and targeted delivery. Solubilization of Naproxen by micellar solutions at 25 degrees C using single and mixed surfactant systems was measured and compared. Solubilization capacity determined with spectrophotometry and tensiometry has been quantified in terms of molar solubilization ratio, micelle-water partition coefficient, and locus of solubilization. Cationic surfactants exhibited higher solubilization capacity than nonionics and anionics, the efficiency increasing with chain length. Mixing effect of surfactants on mixed micelle formation and solubilization efficiency has been discussed in light of regular solution approximation (RSA). Equimolar cationic-nonionic surfactant combinations showed better solubilization capacity than pure cationics or nonionics, which, in general, increased with increase in hydrophobic chain length. Equimolar cationic-nonionic-nonionic ternary surfactant systems exhibited intermediate solubilization efficiency between their single and binary counterparts. Use of RSA has been extended, with fair success, to predict the ...Continue Reading

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Citations

Oct 19, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Dan KeWeiguo Shen
Apr 7, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Xujun LiangStéphane Abel
May 12, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Khalid KhanYahia Mabkhot
Aug 22, 2014·The Journal of Physical Chemistry. B·Seishi Shimizu, Nobuyuki Matubayasi
May 23, 2015·Organic & Biomolecular Chemistry·Lucia BarberaValentina Villari
May 12, 2017·Physical Chemistry Chemical Physics : PCCP·Seishi Shimizu, Nobuyuki Matubayasi
Jan 16, 2019·The Analyst·Seishi ShimizuAdam Voelkel
Dec 2, 2011·Organic & Biomolecular Chemistry·Hong HuangYan-Song Zheng
Apr 29, 2016·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Parvaiz Ahmad BhatAijaz Ahmad Dar
Apr 21, 2021·Physical Chemistry Chemical Physics : PCCP·Seishi Shimizu, Nobuyuki Matubayasi
Apr 3, 2012·The Journal of Physical Chemistry. B·Maria Liria Turco LiveriGennara Cavallaro
Dec 15, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Tanja MehlingIrina Smirnova
Dec 14, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Margarita ValeroCécile A Dreiss
Dec 10, 2016·The Journal of Physical Chemistry. B·Sabyasachi Chatterjee, Gopinatha Suresh Kumar
Jun 5, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Yuri A Diaz FernandezJose M Fernandez Hechavarria
Oct 3, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·D YordanovaS Jakobtorweihen
Feb 19, 2014·The Journal of Physical Chemistry. B·Sandra StormIrina Smirnova
Jun 12, 2020·The Journal of Physical Chemistry. B·Soumyadipta RakshitAnindya Datta

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