Effect of surfactants or a water soluble polymer on the crystal transition of clarithromycin during a wet granulation process

International Journal of Pharmaceutics
Kenji NozawaS Itai

Abstract

To generate products containing a stable form of clarithromycin (CAM) (form II) regardless of the initial crystal form of CAM or type of granulation solvent, the effects of five surfactants, or a water-soluble polymer (macrogol 400) were determined on the crystal transition of CAM. The metastable form (form I) was kneaded with water, after adding surfactants, or a water-soluble polymer. Form II was also kneaded with ethanol, after adding the same additives. The resulting samples were analyzed by powder X-ray diffraction. Form I was completely converted to form II by a wet granulation using water with additives bearing polyoxyethylene chains such as polysorbate 80 (PS80), polyoxyl 40 stearate or macrogol 400. The granulation of the form II using ethanol with these additives did not result in a crystal transition to form I. Furthermore, CAM tablets were manufactured using granules with PS80, and these crystal forms and dissolution behaviors were investigated. As a result, the wet granulation of CAM with PS80 gave CAM tablets containing only form II and PS80 did not have any adverse effects on tablet characteristics. Therefore, these data suggests that the crystal form of CAM can be controlled to be form II using a wet granulation...Continue Reading

References

Mar 11, 1999·Chemical & Pharmaceutical Bulletin·T YajimaS Itai
Sep 8, 2000·Archives of Pharmacal Research·Y T SohnW B Im
Feb 19, 2002·Chemical & Pharmaceutical Bulletin·Toshio YajimaYoshiaki Kawashima
Jan 7, 2011·Journal of the American Chemical Society·Jian TianJerry L Atwood
May 3, 2011·Chemical & Pharmaceutical Bulletin·Sadahiro FujikiShigeru Itai
Feb 7, 2012·Acta Crystallographica. Section C, Crystal Structure Communications·Shuji NoguchiShigeru Itai
Jan 1, 2014·Journal of Pharmaceutical Sciences·Shuji NoguchiShigeru Itai
Jun 9, 2015·Journal of Pharmaceutical Sciences·Sadahiro FujikiShigeru Itai

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