Effect of surgery and radiotherapy on complete blood count, lymphocyte subsets and inflammatory response in patients with advanced oral cancer

BMC Cancer
Tadej DovšakNataša Ihan Hren

Abstract

The immune system has a known role in the aetiology, progression and final treatment outcome of oral squamous cell cancers. The aim of this study was to evaluate the influence of radical surgery and radiotherapy on advanced oral squamous cell carcinoma blood counts, lymphocyte subsets and levels of acute inflammatory response markers. Blood samples were obtained from 56 patients 5 days before and 10 days after surgery, 30 days and 1 year after radiotherapy. The whole blood count, lymphocyte subsets and inflammatory response markers (C-reactive protein, erythrocyte sedimentation rate, leukocyte count, expression of index CD64 and index CD163 on neutrophils and monocytes) were measured, statistically analysed and correlated with clinical treatment outcomes. The post-operative period was characterised by the onset of anaemia, thrombocytosis, lymphopenia with reduced B lymphocyte, T helper cell and NK cell counts, and a rise in acute phase reactants. Immediately after radiotherapy, the anaemia improved, the lymphopenia worsened, and thrombocyte levels returned to pre-treatment values. There was a drop in counts across the T and B cell lines, including a reduction in B lymphocytes, naïve and memory T cells with reduced CD4+ and CD8+...Continue Reading

References

Oct 11, 1975·American Journal of Surgery·Z L Olkowski, S A Wilkins
Jan 19, 1995·The New England Journal of Medicine·K Weinberg, R Parkman
May 29, 1998·Acta Orthopaedica Scandinavica·P V GiannoudisP J Guillou
Mar 2, 1999·The Journal of Experimental Medicine·R E ToesC J Melief
Feb 26, 2000·European Journal of Clinical Investigation·H A LeaverW S Walker
Mar 15, 2000·Surgery·K OgawaT Kajiwara
Jul 16, 2003·International Immunopharmacology·Emma L VerasteguiJohn Hadden
Jun 3, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Iris KussTheresa L Whiteside
Feb 19, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P Boyle, J Ferlay
Apr 21, 2006·The British Journal of Oral & Maxillofacial Surgery·D KissunS N Rogers
Sep 23, 2008·Oral Oncology·Saman Warnakulasuriya
Jun 9, 2009·Oral Oncology·Sunil D KhandavilliRhiannon Whitaker
Jun 16, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zsuzsanna TabiJohn Staffurth
Jul 8, 2010·International Journal of Oral and Maxillofacial Surgery·J J LeeJ H Jeng
Aug 3, 2010·Head & Neck Oncology·Astrid L KruseKlaus W Grätz
Nov 5, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stefano CasertaRose Zamoyska
Dec 24, 2011·Nature·Ira MellmanGlenn Dranoff
Oct 12, 2013·Cancer·Moran AmitUNKNOWN International Consortium for Outcome Research (ICOR) in Head and Neck Cancer
Oct 16, 2013·Oral Oncology·Neil Gildener-LeapmanJulie E Bauman
Nov 27, 2016·BMC Immunology·Hsien LiuTsun-Mei Lin

❮ Previous
Next ❯

Citations

Apr 15, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·K HolubA Biete
May 14, 2020·Cancer Immunology, Immunotherapy : CII·Daniëlle KrijgsmanMarianne Hokland

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection
ESR

Software Mentioned

FlowJo
FACSDiva
Statistical Package for the Social Sciences

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.