Effect of surgery and radiotherapy on visual and endocrine function in nonfunctioning pituitary adenomas

Journal of Endocrinological Investigation
Annamaria ColaoGaetano Lombardi

Abstract

The effect of surgery alone or followed by radiotherapy in recovering visual abnormalities, debulking tumor mass and restoring hormone impairments was evaluated in 84 patients with clinical nonfunctioning pituitary adenomas (NFPA) subjected to 1-10 yr follow-up. All patients underwent surgery via transsphenoidal (in 69) or transcranic-pterional approach (in 15). Radiotherapy was performed after surgery in 59 of 72 patients with incomplete tumor removal. The assessment of pituitary function was performed in all patients before and every 1-2 yr after surgery and/or radiotherapy. Radiological and ophthalmologic assessment was performed before and 3, 6 and 12 months after surgery, then yearly. At diagnosis, headache and visual disturbances occurred in 63 and 58 patients, respectively, while deficiency of GH, TSH, ACTH, FSH, LH and ADH was documented in 55, 7, 19 47 and 6 patients, respectively. After surgery, gonadal function recovered in 12 women, visual disturbances improved in 43 patients (15 regained normal vision), pituitary function improved in 8 of 62 patients, worsened in 34 patients. At MRI, complete tumor removal was documented in 12 of 84 patients. After surgery alone, tumor regrowth was observed in 7 patients between 3-...Continue Reading

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Citations

Aug 16, 2014·Journal of Neurosurgery·Sven BerkmannMichael Buchfelder
Nov 4, 2006·Pituitary·Craig A Jaffe
May 28, 2002·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Hiroshi NishiokaNobuyuki Nakajima
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Feb 22, 2021·Journal of Neuro-oncology·Navid RedjalBrian V Nahed

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