Jun 15, 1999

Effect of surgically induced varicocele on testicular blood flow and Sertoli cell function

H LiC B Dhabuwala


To evaluate the effect of varicocele on testicular blood flow and expression by Sertoli cells of transferrin and androgen-binding protein (ABP), to determine whether varicoceles impair Sertoli cell function. Experimental varicocele was established in male Sprague-Dawley rats by partial ligation of the left renal vein. The control group received a sham operation. At 30 minutes after surgery, rats underwent a xenon-133 washout study, and at 30 days after surgery, transferrin, ABP, and testicular blood flow were evaluated. Expression of transferrin and ABP were evaluated using immunohistochemical techniques. Testicular blood flow was measured using xenon-133 clearance techniques. Statistical analyses were done with an independent t test. The testicular blood flow was 16.7 +/- 1.25 mL/100 g/min in varicocele-bearing rats and 21.01 +/- 0.46 mL/100 g/min in sham-operated rats 30 minutes after surgery. Testicular blood flow remained decreased at 30 days in varicocele-bearing rats (15.12 +/- 1.08 mL/100 g/min) and remained stable in the control group (19.45 +/- 0.55 mL/100 g/min). The expression of transferrin and ABP was significantly reduced in varicocele-bearing rats compared with the control group. Our study suggests that a decreas...Continue Reading

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Mentioned in this Paper

Salicylhydroxamic acid
Transferrin C
Regional Blood Flow
Blood Flow
Rats, Sprague-Dawley
Structure of Sertoli Cell

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