Effect of sustained-release Verapamil on the morning systemic arterial pressure surge during daily activity in patients with systemic hypertension

The American Journal of Cardiology
G A RositoG H Tofler

Abstract

In a placebo-controlled study of 13 subjects with systemic hypertension, sustained-release verapamil reduced the morning surge in systolic pressure by 10.2 mm Hg (p = 0.04), diastolic pressure by 11.1 mm Hg (p = 0.008), and heart rate by 3.3 beats/min (p = 0.17). Blunting of the morning hemodynamic surge may be a mechanism by which verapamil could reduce the risk of plaque disruption and acute coronary events in the morning.

References

Apr 15, 1978·Lancet·M W Millar-CraigE B Raftery
Oct 1, 1987·The American Journal of Cardiology·S N WillichJ E Muller
Jan 1, 1982·Circulation·B A GouldE B Raftery
Sep 1, 1995·Circulation·R A Kloner
Mar 1, 1995·Circulation·E Braunwald
Mar 1, 1994·Journal of the American College of Cardiology·J E MullerG H Tofler

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Citations

May 26, 1999·Current Problems in Cardiology·M FreherM Gheorgiade

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