Effect of swirling blood flow on vortex formation at post-stenosis

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
Hojin HaSang-Joon Lee

Abstract

Various clinical observations reported that swirling blood flow is a normal physiological flow pattern in various vasculatures. The swirling flow has beneficial effects on blood circulation through the blood vessels. It enhances oxygen transfer and reduces low-density lipoprotein concentration in the blood vessel by enhancing cross-plane mixing of the blood. However, the fluid-dynamic roles of the swirling flow are not yet fully understood. In this study, inhibition of material deposition at the post-stenosis region by the swirling flow was observed. To reveal the underlying fluid-dynamic characteristics, pathline flow visualization and time-resolved particle image velocimetry measurements were conducted. Results showed that the swirling inlet flow increased the development of vortices at near wall region of the post-stenosis, which can suppress further development of stenosis by enhancing transport and mixing of the blood flow. The fluid-dynamic characteristics obtained in this study would be useful for improving hemodynamic characteristics of vascular grafts and stents in which the stenosis frequently occurred. Moreover, the time-resolved particle image velocimetry measurement technique and vortex identification method employ...Continue Reading

References

Jan 1, 1978·Journal of Biomechanics·R A Cassanova, D P Giddens
Dec 1, 1990·Journal of Vascular Surgery·M OjhaR S Cobbold
Jun 1, 1984·The Australian and New Zealand Journal of Surgery·J H MillerI Faris
Jan 1, 1980·Circulation·J S SchwartzJ N Cohn
Apr 1, 1995·Journal of Vascular Surgery·J J NorbertoR G DePalma
Sep 1, 1994·The British Journal of Surgery·M G Davies, P O Hagen
Feb 2, 1999·American Journal of Surgery·A T GentileS K Williams
May 3, 2000·Journal of Biomechanical Engineering·S J SherwinC L Dumoulin
Oct 17, 2001·Journal of Biomechanical Engineering·R S KeyntonS E Rittgers
May 5, 2005·Annals of Biomedical Engineering·Thomas O BrienTim McGloughlin
Oct 4, 2005·Physical Review Letters·Gianni Pedrizzetti, Federico Domenichini
Jul 20, 2006·Journal of the Royal Society, Interface·Colin G CaroNick Watkins
Oct 19, 2006·Medical & Biological Engineering & Computing·Kelvin WongDerek Abbott
Dec 13, 2006·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·H J T A M HuijbregtsF L Moll
Nov 27, 2008·Journal of the Royal Society, Interface·G Coppola, C Caro
Aug 14, 2009·Medical Engineering & Physics·Manosh C Paul, Arkaitz Larman
Mar 17, 2010·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·M J KangS J Lee
Sep 26, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Jongho LeeRohit Karnik
Nov 20, 2012·Journal of Biomechanics·K Van CanneytP Verdonck
Sep 3, 2013·Microvascular Research·Hojin Ha, Sang-Joon Lee
Nov 12, 2013·Medical Engineering & Physics·Hojin Ha, Sang-Joon Lee
Dec 18, 2013·Biomedical Engineering Online·Dhanjoo N Ghista, Foad Kabinejadian
Mar 19, 2014·Proceedings of the National Academy of Sciences of the United States of America·Daniele VigoloHoward A Stone
Jul 6, 2014·Medical Engineering & Physics·Hojin Ha, Sang Joon Lee

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Citations

Aug 24, 2018·Current Cardiology Reports·Pablo Huang Zhang, J Yasha Kresh
Jan 22, 2019·Computer Methods in Biomechanics and Biomedical Engineering·B Prashantha, S Anish

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Methods Mentioned

BETA
arterial bypass

Software Mentioned

MATLAB
PIVlab

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